Prolactin suppresses release of luteinising hormone during lactation in the monkey
Prolactin suppresses release of luteinising hormone during lactation in the monkey
复制标题
催乳素抑制猴子哺乳期间黄体生成素的释放
作者：
R. Maneckjee;B. R. Srinath;N. Moudgal
对大鼠的研究表明，在哺乳期，促黄体生成激素（LH）依赖性生理事件（如发情1和发情周期恢复2）受到抑制。这种抑制作用仅发生在哺乳期，并且与此时循环中存在的高水平催乳素相关。虽然外源性催乳素可以替代激烈的吸吮的影响，它可以这样做，只有在允许的影响下，最小的吸吮刺激。我们已经证明，在这些条件下，LH水平降低，这是由于催乳素干扰垂体对LH释放激素（LHRH）的反应性（K。穆拉里达尔河M.和N. R. M.，未出版）。使用哺乳期的猴子，我们现在已经证明了类似的抑制作用，催乳素对垂体LHRH的反应，这表明了一种机制，通过这种机制，闭经的条件下，保持在哺乳期。
STUDIES with rats have shown that during lactation there is an inhibition of luteinising hormone (LH)-dependent physiological events, such as implantation1, and a return to oestrus cyclicity2. This inhibition has been shown to occur only during the intense suckling phase and it has been correlated with the high levels of prolactin present in the circulation at this time. Although exogenous prolactin could substitute for the effects of intense suckling, it could do so only under the permissive influence of minimal suckling stimulus. We have shown that there is, in these conditions, a lowering of LH levels, and that this is due to interference by prolactin with the pituitary responsiveness to LH-releasing hormone (LHRH) (K. Muralidhar, R. M. and N. R. M., unpublished). Using the lactating monkey, we have now demonstrated a similar inhibitory effect of prolactin on pituitary responsiveness to LHRH, suggesting a mechanism by which amenorrhoeic conditions are maintained during lactation.