MicroRNA Machinery Genes as Novel Biomarkers for Cancer.
MicroRNA Machinery Genes as Novel Biomarkers for Cancer.
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MicroRNA 机械基因作为癌症的新型生物标志物
DOI：
10.3389/fonc.2014.00113
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发表时间：
2014
影响因子：
4.7
通讯作者：
Liu SM
中科院分区：
文献类型：
--
作者：
Huang JT;Wang J;Srivastava V;Sen S;Liu SM
microRNAs（miRNAs）直接或间接影响肿瘤的发生。为了能够发挥其无数的作用，miRNA机器基因，如Drosha，DGCR 8，Dicer 1，XPO 5，TRBP和AGO 2，必须产生精确的miRNA。这些基因在不同的癌症中具有特定的表达模式、蛋白质结合伴侣和生化能力。我们对癌症基因组图谱联盟关于多种类型癌症的数据进行的初步分析显示，这些miRNA机制基因发生了显着变化。在这里，我们回顾了它们的生物学结构和功能，着眼于了解它们如何作为癌症生物标志物。
MicroRNAs (miRNAs) directly and indirectly affect tumorigenesis. To be able to perform their myriad roles, miRNA machinery genes, such as Drosha, DGCR8, Dicer1, XPO5, TRBP, and AGO2, must generate precise miRNAs. These genes have specific expression patterns, protein-binding partners, and biochemical capabilities in different cancers. Our preliminary analysis of data from The Cancer Genome Atlas consortium on multiple types of cancer revealed significant alterations in these miRNA machinery genes. Here, we review their biological structures and functions with an eye toward understanding how they could serve as cancer biomarkers.