EFFICACY OF INFLUENZA VACCINE IN NURSING-HOMES - REDUCTION IN ILLNESS AND COMPLICATIONS DURING AN INFLUENZA-A (H3N2) EPIDEMIC
EFFICACY OF INFLUENZA VACCINE IN NURSING-HOMES - REDUCTION IN ILLNESS AND COMPLICATIONS DURING AN INFLUENZA-A (H3N2) EPIDEMIC
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DOI：
10.1001/jama.253.8.1136
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发表时间：
1985-01-01
影响因子：
120.7
通讯作者：
SCHONBERGER, LB
中科院分区：
文献类型：
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作者：
PATRIARCA, PA;WEBER, JA;SCHONBERGER, LB
1982年12月10日至1983年3月4日，当甲型流感（H3N2）病毒在美国密歇根州流行时，在美国密歇根州的7家疗养院中发现了流感样疾病的爆发；1018名居民中有272人（27%）受到影响。未接种疫苗的居民比接种疫苗的居民更容易生病（风险比[RR]， 2.6； 95%可信区间[CI]， 1.8-3.6），随后更容易住院（RR, 2.4; 95% CI, 1.2-4.8），发展成x线摄影证实的肺炎（RR, 2.9; 95% CI, 1.6-5.3）或死亡（RR, 5.6; 95% CI, 1.2-9.1）。在对田纳西县剩余的8所疗养院中的6所进行的调查中得出了类似的观察结果，其中458名居民中有57人（12%）偶尔生病。流感疫苗可以明显降低老年人和慢性病患者中流感病毒感染的发病率和严重程度，并强调了在养老院和一般社区中接种疫苗计划的重要性。
From Dec. 10, 1982 to March 4, 1983, when influenza A (H3N2) viruses circulated in Michigan [USA], outbreaks of influenza-like illness were identified in 7 nursing homes in Genesee County [Michigan, USA]; 272 (27%) of 1,018 residents were affected. Unvaccinated residents were more likely than vaccinated residents to become ill (risk ratio [RR], 2.6; 95% confidence interval [CI], 1.8-3.6) and were subsequently more likely to be hospitalized (RR, 2.4; 95% CI, 1.2-4.8), develop roentgenographically proven pneumonia (RR, 2.9; 95% CI, 1.6-5.3) or die (RR, 5.6; 95% CI, 1.2-9.1). Similar observations were made during investigations in 6 of the 8 remaining nursing homes in Genesee County, in which 57 (12%) of 458 residents became ill sporadically. Influenza vaccine can apparently reduce the incidence and severity of influenza virus infections among the elderly and chronically ill and underscore the importance of vaccination programs for those in nursing homes and in the general community.