Standards of morphological evaluation and histological grading in experimental acute pancreatitis.
Standards of morphological evaluation and histological grading in experimental acute pancreatitis.
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实验性急性胰腺炎形态学评价及组织学分级标准
DOI：
10.1159/000129235
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
H. Aho
中科院分区：
文献类型：
--
作者：
T. Nevalainen;H. Aho
急性胰腺炎的形态学特征为水肿、出血、实质坏死和脂肪坏死。炎症伴随着多形核白细胞的浸润。根据有无坏死可分为间质性（或水肿性）胰腺炎和出血坏死性胰腺炎。可以通过对不同类型的形态改变进行评分或通过确定总小叶实质中坏死组织的比例来在组织学切片中对疾病的严重程度进行分级。前一种方法基于组织学切片的主观评估，适用于评估水肿性和坏死性胰腺炎。坏死实质的组织计量学测量只能用于实验性胰腺炎的坏死形式，例如胰腺炎。导管内注射胆汁、胆汁盐或消化酶诱发的胰腺炎，以及饮食乙硫氨酸诱发的胰腺炎。在评估不同疗法的效果时，组织损伤的分级至关重要。
Acute pancreatitis is characterized morphologically by edema, hemorrhages, parenchymal necrosis and fat necrosis. The inflammation is accompanied by infiltration of polymorphonuclear leukocytes. According to the absence or presence of necrosis the disease can be divided into interstitial (or edematous) pancreatitis and hemorrhagic-necrotizing pancreatitis. The severity of disease can be graded in the histological sections either by giving scores to the different types of morphological alterations or by determining the proportion of necrotic tissue of the total lobular parenchyma. The former method is based on subjective assessment of histological slides and is suitable for the evaluation of both edematous and necrotizing pancreatitis. Histometric measurement of necrotic parenchyma can be used only in the necrotizing forms of experimental pancreatitis, e.g. in those induced by intraductal injection of bile, bile salts or digestive enzymes, and in the dietary ethionine-induced pancreatitis. Grading of the tissue damage is essential when the effects of different therapies are evaluated.