CELLS OF ORIGIN AND TERMINAL DISTRIBUTION OF CORTICOSTRIATAL FIBERS ARISING IN SENSORY-MOTOR CORTEX OF MONKEYS
CELLS OF ORIGIN AND TERMINAL DISTRIBUTION OF CORTICOSTRIATAL FIBERS ARISING IN SENSORY-MOTOR CORTEX OF MONKEYS
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DOI：
10.1002/cne.901730105
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发表时间：
1977-01-01
影响因子：
2.5
通讯作者：
PORTER, R
中科院分区：
文献类型：
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作者：
JONES, EG;COULTER, JD;PORTER, R
用辣根过氧化物酶逆行方法对松鼠[Saimiri scureus]皮质纹状体投射的起源细胞进行了鉴定。在大脑皮层的躯体感觉、运动、顶叶和额区的亚区，投射到同侧纹状体的细胞分布较稀疏，形成一群中小型锥体细胞，其胞体直径从一个区域到另一个区域的平均直径为14-16微米。这样的细胞只存在于皮质的V层(主要是较浅层的部分)。由于皮质纹状体轴突始终小于投射到脑干和脊髓的第V层锥体细胞，而且由于它们位于第VI层之外，因此皮质纹状体轴突不太可能是投射到其他部位的轴突的侧支。交叉皮质纹状体投射的起源细胞也位于V层，为锥体细胞，其胞体直径与上文相同。用顺行放射自显影方法对恒河猴[猕猴]、食蟹猴[束猴]和松鼠进行的研究表明，躯体感觉区投射到同侧壳核的大部分前后部。躯体感觉皮质的3a、3b、1和2亚区投射到同一区域，并且该投射与来自运动和大脑皮层某些其他区域的同样广泛的投射重叠。在每种情况下，终端标签的图案都是中断的簇、条和带的形式。皮质的一次小注射只与1或2个这样的末端标记簇有关。显然，单个皮质纹状体纤维以一种非常有限的方式结束，来自一个皮质区域的纤维的终末分支可能在壳核与其他区域的纤维分支交替。
The cells of origin of the corticostriatal projection were identified in squirrel monkeys [Saimiri sciureus] by the retrograde horseradish peroxidase method. In the subfields of the somatic sensory, motor, parietal and frontal areas of the cortex, cells projecting to the ipsilateral striatum are relatively sparsely distributed and form a group of small- to medium-sized pyramidal cells with an average somal diameter from area to area of 14-16 .mu.m. Such cells are found only in layer V of the cortex (mainly in the more superficial parts of the layer). Since they are consistently smaller than the pyramidal cells of layer V that project to the brainstem and spinal cord and since they lie outside layer VI which gives rise to corticothalamic axons, the corticostriatal axons are unlikely to be collaterals of axons projecting to other sites. The cells of origin of the crossed corticostriatal projection are also found in layer V and are pyramidal cells with somal diameters in the same range as above. They are found only in areas 4, 8 and 6. Studies with the anterograde, autoradiographic method in rhesus [Macaca mulatta], cynomologous [M. fascicularis] and squirrel monkeys, indicated that the somatic sensory areas project to most of the antero-posterior extent of the ipsilateral putamen. Subareas 3a, 3b, 1 and 2 of the somatic sensory cortex project to the same region and the projection overlaps similarly extensive projections from the motor and certain other areas of the cortex. In each case the pattern of terminal labeling is in the form of interrupted clusters, strips and bands. A single small injection of the cortex is associated with only 1 or 2 such clusters of terminal labeling. Apparently individual corticostriatal fibers end in a very restricted manner and that the terminal ramifications of fibers from one cortical area may alternate in the putamen with those arising in other areas.