Modeling of a segmented electrode for desynchronizing deep brain stimulation.
Modeling of a segmented electrode for desynchronizing deep brain stimulation.
复制标题
DOI：
10.3389/fneng.2011.00015
复制
发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Hauptmann C
中科院分区：
文献类型：
--
作者：
Buhlmann J;Hofmann L;Tass PA;Hauptmann C
深部脑刺激（DBS）是治疗帕金森病等医学难治性运动障碍的有效疗法。植入人脑目标区域的电极会产生电场，激活附近的神经纤维和细胞体。尽管不同的目标核在其解剖结构上表现出相当大的差异，但目前只有少数类型的电极可商用。期望以可以减少副作用的方式调节电场，特别是相对于相应的目标核在电极周围激活的组织的体积。此外，对于新型刺激策略（例如协调重置神经调节）的最佳应用，目标结构的更具选择性和部分激活是可取的。因此，我们设计了一种分段设计的 DBS 电极，可以更有选择性地激活目标结构。我们创建了电极的有限元模型 (FEM)，并分析了为此电极设计激活的组织体积。分段电极以有针对性的方式激活一个区域，该区域相对于电极的尺寸和位置可以通过调整每个电极接触的刺激参数来控制。根据我们的计算分析，这种定向刺激可能优于副作用的发生，并且它使得能够在最佳条件下应用协调重置神经调节。
Deep brain stimulation (DBS) is an effective therapy for medically refractory movement disorders like Parkinson’s disease. The electrodes, implanted in the target area within the human brain, generate an electric field which activates nerve fibers and cell bodies in the vicinity. Even though the different target nuclei display considerable differences in their anatomical structure, only few types of electrodes are currently commercially available. It is desirable to adjust the electric field and in particular the volume of tissue activated around the electrode with respect to the corresponding target nucleus in a such way that side effects can be reduced. Furthermore, a more selective and partial activation of the target structure is desirable for an optimal application of novel stimulation strategies, e.g., coordinated reset neuromodulation. Hence we designed a DBS electrode with a segmented design allowing a more selective activation of the target structure. We created a finite element model (FEM) of the electrode and analyzed the volume of tissue activated for this electrode design. The segmented electrode activated an area in a targeted manner, of which the dimension and position relative to the electrode could be controlled by adjusting the stimulation parameters for each electrode contact. According to our computational analysis, this directed stimulation might be superior with respect to the occurrence of side effects and it enables the application of coordinated reset neuromodulation under optimal conditions.