Malignant Melanoma of the Iris a 25-Year Analysis of Danish Cases
Malignant Melanoma of the Iris a 25-Year Analysis of Danish Cases
复制标题
丹麦虹膜恶性黑色素瘤病例 25 年分析
DOI：
10.1177/112067219300300402
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发表时间：
1993
影响因子：
1.7
通讯作者：
O. A. Jensen
中科院分区：
文献类型：
--
作者：
O. A. Jensen
本研究基于眼科病理研究所的资料，对丹麦虹膜恶性黑色素瘤进行了长达25年的研究。1961 ~ 1985年共发现80例，男41例，女39例，中位年龄53岁，范围8 ~ 83岁。这意味着平均每年3.2例，平均人口为490万。与脉络膜的恶性黑色素瘤相反，观察到增加。原因尚不清楚，虽然暴露于光化射线可能是一个因素。超过三分之一的病例靠近瞳孔，略少于三分之一的病例侵犯腔角/睫状体。10例为环状黑色素瘤。一半的肿瘤为梭形细胞，四分之一为混合细胞，少数呈上皮样或瘤样细胞形态。其中虹膜切除术28例，原发性去核27例，继发性去核10例。15例行虹膜睫状体切除术。所有病人都能被追踪到。在随访日（1991年12月1日），8例患者因转移而死亡；其中4名患者患有环状黑色素瘤，4名患者患有侵袭睫状体的肿瘤。虹膜环切除术后，仅记录了一例转移性死亡——一例不完全切除。强调环形黑色素瘤的严重预后。
This study examined malignant melanoma of the iris in Denmark over a 25-year period on the basis of the files of the Eye Pathology Institute. From 1961 to 1985 a total of 80 cases were found (41 males, 39 females; median age 53 years, range 8 - 83). This means an average of 3.2 cases/year with an average population of 4.9 million. In contrast to malignant melanoma of the choroid, an increase was observed. The reason is not known, although exposure to actinic rays may be a factor. More than a third of cases were close to the pupil, a little less than a third invaded the chamber angle/ciliary body. Ten cases were ring melanomas. Half of the tumours were spindle-celled, a quarter mixed and a few epithelioid or naevoid in cell morphology. Iridectomy was performed in 28 cases, primary enucleation in 27 and secondary enucleation in ten. Iridocyclectomy was performed in 15 cases. All patients could be traced. At the date of follow-up (Dec. 1, 1991) eight had died with metastases; four of these were patients with ring melanoma and four with tumours invading the ciliary body. After iridocyclectomy, only one metastatic death was recorded –- a case of incomplete resection. The grave prognosis of a ring melanoma is highlighted.