Biodegradable polymeric drug delivery systems
Biodegradable polymeric drug delivery systems
复制标题
可生物降解的聚合物药物输送系统
DOI：
--
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
S. W. Kim
中科院分区：
文献类型：
--
作者：
S. Jeong;S. W. Kim
使用可生物降解的聚合物材料作为药物载体是聚合物药物递送系统中相对较新的领域。目前正在研究许多可生物降解或可生物侵蚀的聚合物，例如聚（乳酸/乙醇酸）共聚物、聚（α-氨基酸）、聚酸酐和聚（原酸酯）。这些聚合物可用于基质和储库型递送装置。此外，当化学官能团被引入到可生物降解的聚合物主链上时，例如聚(N-(2-羟丙基)甲基丙烯酰胺)，治疗剂可以直接或通过间隔基共价结合到主链聚合物上。这些聚合物/药物缀合物代表了可生物降解的聚合物药物递送系统的另一个新维度。在本文中，主要重点放在可生物降解聚合物递送系统的临床应用。此外，还将讨论目前正在研究的可生物降解聚合物药物输送系统的例子，以证明这一新领域的潜在重要性。
The use of biodegradable polymeric materials as drug carriers is a relatively new dimension in polymeric drug delivery systems. A number of biodegradable or bioerodible polymers, such as poly (lactic/glycolic acid) copolymer, poly(α-amino acid), polyanhydride, and poly (ortho ester) are currently being investigated for this purpose. These polymers are useful for matrix and reservoir-type delivery devices. In addition, when chemical functional groups are introduced to the biodegradable polymer backbone, such as poly (N-(2-hydroxypropy) methacrylamide), the therapeutic agent can be covalently bound directly orvia spacer to the backbone polymer. These polymer/drug conjugates represent another new dimension in biodegradable polymeric drug delivery systems. In this paper, major emphasis is placed on clinical applications of biodegradable polymeric delivery systems. In addition, examples of biodegradable polymeric durg delivery systems currently being investigated will be discussed for the purpose of demonstrating the potential importance of this new field.
DOI：
10.1016/0006-291x(81)91644-2
发表时间：
1981-01-01
影响因子：
3.1
作者：
SHEN, WC;RYSER, HJP
通讯作者：
RYSER, HJP