Metabolic and behavioral deficits following a routine surgical procedure in rats
Metabolic and behavioral deficits following a routine surgical procedure in rats
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DOI：
10.1016/j.brainres.2007.01.134
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发表时间：
2007-05-04
期刊：
影响因子：
2.9
通讯作者：
Schiffer, Wynne K.
中科院分区：
文献类型：
--
作者：
Frumberg, David B.;Fernando, Marion S.;Schiffer, Wynne K.
为了验证手术脑损伤后观察到的功能性代谢缺陷与啮齿动物认知能力变化有关的假设，我们在对照动物和手术植入动物的行为测量中进行了一系列成像研究。在手术前3天、手术后3天、7天、14天和56天使用新物体识别（NOR）测试评估记忆功能。在每个时间点，还测量了一般运动。术后28天和58天分别用F-18-氟脱氧葡萄糖（[F-18]FDG）进行代谢成像。植入手术的动物在物体识别测试中表现明显较差，而一般运动不受植入物的影响。手术后，与对侧半球相比，植入物同侧半球的大部分半球的葡萄糖摄取明显减少。在这两个时间点，最显著的代谢缺陷发生在初级运动皮层(-25%;p
To test the hypothesis that functional metabolic deficits observed following surgical brain injury are associated with changes in cognitive performance in rodents, we performed serial imaging studies in parallel with behavioral measures in control animals and in animals with surgical implants. Memory function was assessed using the novel object recognition (NOR) test, administered 3 days prior to and 3, 7, 14 and 56 days after surgery. At each time point, general locomotion was also measured. Metabolic imaging with F-18-fluorodeoxyglucose ([F-18]FDG) occurred 28 and 58 days after surgery. Animals with surgical implants performed significantly worse on tests of object recognition, while general locomotion was unaffected by the implant. There was a significant decrease in glucose uptake after surgery in most of the hemisphere ipsilateral to the implant relative to the contralateral hemisphere. At both time points, the most significant metabolic deficits occurred in the primary motor cortex (-25%; p