Increased serum ferritin levels in amyotrophic lateral sclerosis (ALS) patients
Increased serum ferritin levels in amyotrophic lateral sclerosis (ALS) patients
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DOI：
10.1007/s00415-008-0945-0
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发表时间：
2008-11-01
影响因子：
6
通讯作者：
Morrison, Karen E.
中科院分区：
文献类型：
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作者：
Goodall, Emily F.;Haque, Mohammad S.;Morrison, Karen E.
铁失调促进氧化应激，神经退行性疾病的病理机制。本研究旨在评价60例肌萎缩侧索硬化（ALS）患者和44例年龄匹配的对照者的血清铁代谢指标。与对照组相比，ALS患者血清铁蛋白水平显著升高（p < 0.001），而血清铁、转铁蛋白、铁饱和度或总铁结合力水平无差异，同样，C反应蛋白（CRP）或血浆铜蓝蛋白水平也无差异，表明ALS患者铁蛋白水平升高不仅表明急性期反应。铁蛋白水平的增加可能反映了储存的铁的普遍增加，或者是正在进行的肌肉退化的结果。
Iron misregulation promotes oxidative stress, a proposed pathological mechanism in neurodegenerative disease. The aim of this study was to evaluate serum iron metabolism indicators in 60 amyotrophic lateral sclerosis (ALS) patients and 44 age matched controls. Serum ferritin levels were significantly increased in ALS patients compared to controls (p < 0.001), while no differences in the levels of serum iron, transferrin, iron saturation or total iron binding capacity were found. Likewise no differences in C reactive protein (CRP) or caeruloplasmin were detected, suggesting that the elevated ferritin levels in ALS did not merely indicate an acute phase response. The increased ferritin level may reflect a general increase in stored iron or be a consequence of ongoing muscle degeneration.