Increased 18F-FDG uptake suggests synovial inflammatory reaction with osteoarthritis: preliminary in-vivo results in humans.
Increased 18F-FDG uptake suggests synovial inflammatory reaction with osteoarthritis: preliminary in-vivo results in humans.
复制标题
18F-FDG 摄取增加提示滑膜炎症反应与骨关节炎：人类体内的初步结果。
DOI：
10.1097/mnm.0000000000000376
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发表时间：
2015
影响因子：
1.5
通讯作者：
Alavi,Abass
中科院分区：
文献类型：
--
作者：
Parsons,MollyA;Moghbel,Mateen;Saboury,Babak;Torigian,DrewA;Werner,ThomasJ;Rubello,Domenico;Basu,Sandip;Alavi,Abass
目的采用[18F]-2-氟-2-脱氧-D-葡萄糖(18F-FDG)-PET显像，比较临床上有膝关节疼痛(如反复关节痛、关节不稳定和功能受限)的膝关节疼痛患者和无此症状的患者膝关节代谢活动的差异。患者被问及是否有任何关节疼痛，如果有，哪些关节受到影响。结果共有18个未安装假体的膝关节报告疼痛。测量18个膝关节的关节中部间隙和外侧滑膜组织的最大标准摄取值(SUV Max)，并与一组无症状对照膝关节进行比较。疼痛膝关节中部的SUVmax平均值为1.35±0.59，而对照组的平均值为0.86±0.14(P=0.0176)。关节疼痛关节外侧滑膜的最大摄取值为1.17±0.49，对照组为0.73±0.31(P=0.0161)。结论骨关节炎患者18F-FDG摄取增加与膝关节疼痛有关，且两者呈正相关。
ObjectiveThe aim of this prospective study was to compare the metabolic activity of the knee joints of a group of patients with painful knees clinically (such as recurrent joint pain, joint instability, and functional limitations) consistent with osteoarthritis and those of another group of patients without such complaints, using [18 F]-2-fluoro-2-deoxy-D-glucose (18 F-FDG)-PET imaging.MethodsA total of 97 patients who participated in either painful joint prosthesis or diabetic foot research studies involving 18 F-FDG-PET scans were asked to complete a knee pain questionnaire. The patients were asked whether they experienced pain in any joint, and if so, which joints were affected.ResultsA total of 18 knee joints without prosthesis were reported to be painful. The maximum standardized uptake values (SUV max) of the middle joint space and lateral synovial tissue of these 18 knees were measured and compared with those of a set of patients with control asymptomatic knees. The average SUV max of the middle part of the joint space in the painful knees was 1.35±0.59 compared with an average SUV max value of 0.86±0.14 in the control group (P= 0.0176). The average SUV max of the synovium in the lateral part of the painful joints was 1.17±0.49 compared with 0.73±0.31 in the control group (P= 0.0161).ConclusionThese data indicate that increased 18 F-FDG uptake is associated with knee pain in osteoarthritis patients and that there is a positive relationship between the two parameters.