Animal models of ovarian cancer.
Animal models of ovarian cancer.
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DOI：
10.1186/1477-7827-1-67
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发表时间：
2003-10-07
期刊：
影响因子：
--
通讯作者：
Ethier, Jean-Francois
中科院分区：
文献类型：
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作者：
Vanderhyden, Barbara C;Shaw, Tanya J;Ethier, Jean-Francois
卵巢癌是所有妇科癌症中最致命的，可以发生于卵巢的任何细胞类型，包括生殖细胞、颗粒细胞或基质细胞。然而，大多数卵巢癌起源于表面上皮，这是覆盖在卵巢表面的单层细胞。由于缺乏可靠和特异的早期检测上皮性卵巢癌的方法，导致诊断通常发生在临床晚期，此时治疗效果较差。在某种程度上，诊断工具的不足是由于缺乏检测上皮细胞癌前病变或早期肿瘤变化的标志物，这反映了我们对这一过程的相当糟糕的理解。准确反映与卵巢癌发生和发展相关的细胞和分子变化的动物模型具有促进卵巢癌早期发现和治疗的更好方法的巨大潜力。本文综述了已报道的一些卵巢肿瘤发生的实验动物模型，包括涉及特定生殖因素和环境毒素的动物模型。还考虑了使用基因工程小鼠建立卵巢癌模型的最新进展。
Ovarian cancer is the most lethal of all of the gynecological cancers and can arise from any cell type of the ovary, including germ cells, granulosa or stromal cells. However, the majority of ovarian cancers arise from the surface epithelium, a single layer of cells that covers the surface of the ovary. The lack of a reliable and specific method for the early detection of epithelial ovarian cancer results in diagnosis occurring most commonly at late clinical stages, when treatment is less effective. In part, the deficiency in diagnostic tools is due to the lack of markers for the detection of preneoplastic or early neoplastic changes in the epithelial cells, which reflects our rather poor understanding of this process. Animal models which accurately represent the cellular and molecular changes associated with the initiation and progression of human ovarian cancer have significant potential to facilitate the development of better methods for the early detection and treatment of ovarian cancer. This review describes some of the experimental animal models of ovarian tumorigenesis that have been reported, including those involving specific reproductive factors and environmental toxins. Consideration has also been given to the recent progress in modeling ovarian cancer using genetically engineered mice.