NIR Photoresponsive Crosslinked Upconverting Nanocarriers Toward Selective Intracellular Drug Release
NIR Photoresponsive Crosslinked Upconverting Nanocarriers Toward Selective Intracellular Drug Release
复制标题
DOI：
10.1002/smll.201201765
复制
发表时间：
2013-09-09
期刊：
影响因子：
13.3
通讯作者：
Xing, Bengang
中科院分区：
文献类型：
--
作者：
Yang, Yanmei;Velmurugan, Bhaarathy;Xing, Bengang
开发了一种近红外响应介孔二氧化硅包覆的上转换纳米颗粒（UCNP）缀合物，用于活细胞中的可控药物递送和荧光成像。在这项工作中，抗肿瘤药物阿霉素（Dox）分子被封装在交联的光笼介孔二氧化硅涂层UCNPs。在980 nm光照射下，Dox可通过UCNPs转换的紫外光选择性地裂解邻硝基苄基（NB）笼状连接体而释放。这种NIR光响应纳米颗粒缀合物证明了药物在癌细胞中的控制释放的高效率。在用叶酸（FA）官能化纳米载体后，这种光笼化的FA缀合的二氧化硅-UCNP纳米载体还将允许靶向细胞内药物递送和对具有高水平表达叶酸受体（FR）的细胞系的选择性荧光成像。
An NIR-responsive mesoporous silica coated upconverting nanoparticle (UCNP) conjugate is developed for controllable drug delivery and fluorescence imaging in living cells. In this work, antitumor drug doxorubicin (Dox) molecules are encapsulated within cross-linked photocaged mesoporous silica coated UCNPs. Upon 980 nm light irradiation, Dox could be selectively released through the photocleavage of theo-nitrobenzyl (NB) caged linker by the converted UV emission from UCNPs. This NIR light-responsive nanoparticle conjugate demonstrates high efficiency for the controlled release of the drug in cancer cells. Upon functionalization of the nanocarrier with folic acid (FA), this photocaged FA-conjugated silica-UCNP nanocarrier will also allow targeted intracellular drug delivery and selective fluorescence imaging towards the cell lines with high level expression of folate receptor (FR).