One-pot three-component approach to the synthesis of polyfunctional pyrazoles.
One-pot three-component approach to the synthesis of polyfunctional pyrazoles.
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DOI：
10.1021/ol402810f
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发表时间：
2013-11
期刊：
影响因子：
5.2
通讯作者：
Guolin Zhang;Hangcheng Ni;Wenteng Chen;Jiaan Shao;Huan Liu;Binhui Chen;Yongping Yu
中科院分区：
文献类型：
--
作者：
Guolin Zhang;Hangcheng Ni;Wenteng Chen;Jiaan Shao;Huan Liu;Binhui Chen;Yongping Yu
叠氮化乙烯、醛和甲苯磺酰肼的简单、多组分、直接反应可在碱存在下以中等至优异的产率区域选择性地构建 3,4,5-三取代的 1H-吡唑。该方法可以容忍一系列功能，并提出了一种可能的机制。
A simple, multicomponent, and straightforward reaction of vinyl azide, aldehyde, and tosylhydrazine affords the construction of 3,4,5-trisubstituted 1H-pyrazoles regioselectively in the presence of base with moderate to excellent yields. A range of functionality could be tolerated in this methodology, and a possible mechanism is proposed.