Relationship of retinal vascular caliber with diabetes and retinopathy - The Multi-Ethnic Study of Atherosclerosis (MESA)
Relationship of retinal vascular caliber with diabetes and retinopathy - The Multi-Ethnic Study of Atherosclerosis (MESA)
复制标题
DOI：
10.2337/dc07-1528
复制
发表时间：
2008-03-01
期刊：
影响因子：
16.2
通讯作者：
Wong, Tien Yin
中科院分区：
文献类型：
--
作者：
Nguyen, Thanh Tan;Wang, Jie Jin;Wong, Tien Yin
目的-研究视网膜血管口径与糖尿病，糖尿病和糖尿病retinopathy.RESEARCH设计和方法的关系-基于人口的研究，使用来自动脉粥样硬化的多种族研究（梅萨），包括5,976个人（白人，黑人，西班牙裔和中国人）居住在六个美国社区的数据在基线时没有临床心血管疾病。视网膜血管口径从数字视网膜photographs.RESULTS测量-有4,585例空腹血糖正常（NFG），499例空腹血糖受损（IFG），165例糖尿病视网膜病变的迹象，和727例糖尿病00无视网膜病变的迹象。多因素分析后，视网膜小动脉口径从NFG患者的143.8 μ m增加到IFG患者的144.5 μ m和糖尿病患者的146.1 μ m（趋势P < 0.001）。视网膜微静脉口径从NFG的214.4 μ m增加到IFG的216.7 μ m和糖尿病的218.0 μ m（趋势P < 0.001）。随着空腹血糖和AlC水平的升高，视网膜微静脉口径明显增大。在按种族进行的亚组分析中，仅白人中小动脉口径较宽与糖尿病之间的相关性明显，而仅西班牙裔和中国人中小静脉口径较宽与糖尿病之间的相关性明显。在糖尿病患者中，视网膜病变的眼睛有较大的视网膜小静脉口径，但没有小动脉口径。结论-视网膜小动脉和小静脉口径在糖尿病患者中较大，但相关模式似乎因种族而异。视网膜小静脉口径还与视网膜病变体征相关。这些发现进一步增加了视网膜血管口径的变化可能反映早期糖尿病微血管损伤的概念。
OBJECTIVE - To examine the relationship of retinal vascular caliber with diabetes, glycemia, and diabetic retinopathy.RESEARCH DESIGN AND METHODS - Population-based study using data from the Multi-Ethnic Study of Atherosclerosis (MESA), comprising 5,976 individuals (whites, blacks, Hispanics, and Chinese) residing in six U.S. communities who were free of clinical cardiovascular disease at baseline. Retinal vascular caliber was measured from digital retinal photographs.RESULTS - There were 4,585 individuals with normal fasting glucose (NFG), 499 with impaired fasting glucose (IFG), 165 with diabetes with retinopathy signs, and 727 with diabetes 00 without retinopathy signs. After multivariate analysis, retinal arteriolar caliber increased from 143.8 mu m in subjects with NFG to 144.5 mu m in IFG and 146.1 mu m in diabetes (P < 0.001 for trend). Retinal venular caliber increased from 214.4 mu m in NFG to 216.7 mu m in IFG and 218.0 mu m in diabetes (P < 0.001 for trend). Retinal venular caliber was significantly larger with increasing levels of fasting glucose and AlC. In a subgroup analysis by ethnicity, the association between wider arteriolar caliber and diabetes was evident in whites only, whereas wider venular caliber and diabetes was evident in Hispanics and Chinese only. in people with diabetes, eyes with retinopathy had larger retinal venular but not arteriolar caliber.CONCLUSIONS - Retinal arteriolar and venular calibers are larger in individuals with diabetes, but the pattern of associations appears to vary by ethnicity. Retinal venular caliber is additionally associated with retinopathy signs. These findings add further to the concept that variations in retinal vascular caliber may reflect early diabetic microvascular damage.