Mefenamic acid as a novel activator of L‐type voltage‐dependent Ca2+ channels in smooth muscle cells from pig proximal urethra
Mefenamic acid as a novel activator of L‐type voltage‐dependent Ca2+ channels in smooth muscle cells from pig proximal urethra
复制标题
甲芬那酸作为猪近端尿道平滑肌细胞 L 型电压依赖性 Ca2+ 通道的新型激活剂
DOI：
10.1038/sj.bjp.0706051
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发表时间：
2005
影响因子：
7.3
通讯作者：
Y. Ito
中科院分区：
文献类型：
--
作者：
N. Teramoto;T. Tomoda;Y. Ito
1 The effects of mefenamic acid and Bay K 8644 on voltage‐dependent nifedipine‐sensitive inward Ba2+ currents in pig urethral myocytes were investigated by use of conventional whole‐cell configuration patch clamp. 2 Mefenamic acid increased the peak amplitude of voltage‐dependent nifedipine‐sensitive inward Ba2+ current without shifting the position of the current–voltage relationship. 3 Mefenamic acid (300 μM) caused little shift in the activation curve although the voltage dependence of the steady‐state inactivation was shifted to more positive potentials by 11 mV in the presence of mefenamic acid. 4 Bay K 8644 (100 nM) enhanced voltage‐dependent nifedipine‐sensitive inward Ba2+ currents in a concentration‐ and voltage‐dependent manner, shifting the maximum of the current–voltage relationship by 10 mV in the hyperpolarizing direction. 5 Bay K 8644 (1 μM) significantly shifted the voltage dependence of the activation curve to more negative potentials by approximately 9 mV although Bay K 8644 caused little shift in the steady‐state inactivation curve. 6 These results indicate that mefenamic acid increased voltage‐dependent nifedipine‐sensitive inward Ba2+ currents through the activation of L‐type Ca2+ channels with different kinetics from those of Bay K 8644 in pig urethral myocytes.
由非二氢吡啶 FPL 64176 定义的心脏钙通道激活的新位点。
DOI：
--
发表时间：
1991
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
Rampe,D;Lacerda,AE
通讯作者：
Lacerda,AE
影响因子：
3.4
作者：
OTTOLIA, M;TORO, L
通讯作者：
TORO, L