Interactions between three typical endocrine-disrupting chemicals (EDCs) in binary mixtures exposure on myocardial differentiation of mouse embryonic stem cell.
Interactions between three typical endocrine-disrupting chemicals (EDCs) in binary mixtures exposure on myocardial differentiation of mouse embryonic stem cell.
复制标题
DOI：
10.1016/j.chemosphere.2017.03.040
复制
发表时间：
2017-07
期刊：
影响因子：
8.8
通讯作者：
Ren Zhou;W. Cheng;Yan Feng;Hongying Wei;Fan Liang;Yan Wang
中科院分区：
文献类型：
--
作者：
Ren Zhou;W. Cheng;Yan Feng;Hongying Wei;Fan Liang;Yan Wang
近年来，在人体血液和尿液中检测到多种内分泌干扰物（EDCs）。因此，研究内分泌干扰物的联合毒性作用具有重要意义。在本研究中，我们评估了三个典型的内分泌干扰物：全氟辛烷磺酸（PFOS），全氟辛酸（PFOA），双酚A（BPA）的胚胎干细胞试验（EST）的个体和联合发育毒性。本研究探讨了同一化学基团组合与不同化学基团组合的异同。结果表明，三种化合物均为弱胚胎毒性。PFOS和BPA联合暴露对心肌分化有协同作用。然而，在所有终点中，PFOA与PFOS或BPA之间的综合效应都是相加作用。因此，我们得出结论，在大多数不同的EDC混合物中，无论它们是否具有相似的结构，都存在加和效应。另一方面，在属于不同化学基团的EDCs的混合物中观察到协同作用。
In recent years, various kinds of endocrine-disrupting chemicals (EDCs) have been detected in human blood and urine. Thus, it was important to investigate the combined toxicity effect of EDCs. In the present study, we evaluated the individual and combined developmental toxicities of three classic EDCs: perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA), and bisphenol A (BPA) by embryonic stem cell test (EST). The similarities and differences between combination of same chemical group as well as different chemical groups were investigated in this research. Our results showed that the three compounds were all classified as weak embryotoxicity. The results of co-exposure revealed that there was synergistic action in combination of PFOS and BPA on myocardial differentiation. However, in all endpoints, the combined effects between PFOA with PFOS or BPA were both additive action. Therefore, we concluded that the additive effects were found in most different EDC mixtures whether they had similar structure or not. On the other hand, synergistic action was observed in a mixture of EDCs that belonged to a different chemical groups.