Vitamin D Production after UVB Exposure Depends on Baseline Vitamin D and Total Cholesterol but Not on Skin Pigmentation
Vitamin D Production after UVB Exposure Depends on Baseline Vitamin D and Total Cholesterol but Not on Skin Pigmentation
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DOI：
10.1038/jid.2009.323
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发表时间：
2010-02-01
影响因子：
6.5
通讯作者：
Wulf, Hans C.
中科院分区：
文献类型：
--
作者：
Bogh, Morten K. B.;Schmedes, Anne V.;Wulf, Hans C.
UVB辐射增加血清维生素D水平，表达为25-羟基维生素D-3 (25(OH)D)，但皮肤色素沉着、基线25(OH)D水平和总胆固醇的影响尚未得到很好的表征。为了确定皮肤色素沉着、基线25(OH)D水平和总胆固醇对UVB暴露后25(OH)D产生的重要性，对182人进行了25(OH)D水平筛查。共选择50名基线25(OH)D水平范围广泛的参与者来定义基线25(OH)D水平的重要性。其中，28名过去很少晒太阳的不崇拜太阳的人被用来研究皮肤色素沉着和基线总胆固醇的影响。参与者将24%的皮肤暴露在UVB（3个标准红斑剂量）下，每隔2天或3天4次。在照射前后测量皮肤色素沉着和25(OH)D水平。在基线时测量总胆固醇。UVB暴露后25(OH)D水平的升高与基线25(OH)D水平呈负相关(P
UVB radiation increases serum vitamin D level expressed as 25-hydroxyvitamin-D-3 (25(OH)D), but the influence of skin pigmentation, baseline 25(OH)D level, and total cholesterol has not been well characterized. To determine the importance of skin pigmentation, baseline 25(OH)D level, and total cholesterol on 25(OH)D production after UVB exposure, 182 persons were screened for 25(OH)D level. A total of 50 participants with a wide range in baseline 25(OH)D levels were selected to define the importance of baseline 25(OH)D level. Of these, 28 non-sun worshippers with limited past sun exposure were used to investigate the influence of skin pigmentation and baseline total cholesterol. The participants had 24% of their skin exposed to UVB (3 standard erythema doses) four times every second or third day. Skin pigmentation and 25(OH)D levels were measured before and after the irradiations. Total cholesterol was measured at baseline. The increase in 25(OH)D level after UVB exposure was negatively correlated with baseline 25(OH)D level (P