Measurement of the hepatitis B core-related antigen is valuable for predicting the pathological status of liver tissues in chronic hepatitis B patients
Measurement of the hepatitis B core-related antigen is valuable for predicting the pathological status of liver tissues in chronic hepatitis B patients
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DOI：
10.1016/j.jviromet.2016.05.016
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发表时间：
2016-09-01
影响因子：
3.1
通讯作者：
Feng, Yan-Ling
中科院分区：
文献类型：
--
作者：
Zhang, Zhan-Qing;Lu, Wei;Feng, Yan-Ling
本研究旨在评价血清B型肝炎核心相关抗原（HBcrAg）对慢性B型肝炎（CH B）肝组织病理状态的预测价值。共205例中国CHB患者入组本研究，其中HBeAg阳性121例，HBeAg阴性84例。HBeAg阳性患者血清HBcrAg预测重度坏死性炎症和晚期纤维化的AUC均大于0.70;以血清HBcrAg ≤ 4.81 × 10（4）kU mL（-1）和≤ 2.45 × 10（4）kU mL（-1）为界值，预测重度坏死性炎症和晚期纤维化的敏感性、特异性和准确性分别为0.697，分别为0.716、0.711和0.818、0.778、0.785。在HBeAg阴性的患者中，血清HBcrAg预测严重坏死性炎症和严重纤维化的ADC值均大于0.70;以血清HBcrAg ≥ 1.70 × 10（2）kU mL（-1）和≥ 4.02 kU mL（-1）作为临界值，预测严重坏死性炎症和严重纤维化的敏感性、特异性和准确性分别为0.929、0.964，0.952和1.000、1.000、1.000。这些结果表明，血清HBcrAg预测HBeAg阳性患者的严重坏死性炎症和晚期纤维化以及阴性患者的显著坏死性炎症和显著纤维化的良好性能。(C)2016爱思唯尔B. V.保留所有权利。
The objective of this study was to evaluate the validities of serum hepatitis B core-related antigen (HBcrAg) for predicting the pathological status of liver tissues of chronic hepatitis B (CHB). A total of 205 Chinese patients with CHB, including 121 HBeAg-positive and 84 HBeAg-negative patients, were enrolled in this study. In HBeAg-positive patients, AUCs of serum HBcrAg for predicting severe necro-inflammation and advanced fibrosis were greater than 0.70; using serum HBcrAg < = 4.81 x 10(4) kU mL(-1) and < = 2.45 x 10(4) kU mL(-1) as cutoffs, the sensitivities, specificities, accuracies for predicting severe necro-inflammation and advanced fbrosis were 0.697, 0.716, 0.711 and 0.818, 0.778, 0.785, respectively. In HBeAg-negative patients, the ADCs of serum HBcrAg for predicting significant necro-inflammation and significant fibrosis were greater than 0.70; using serum HBcrAg > = 1.70 x 10(2) kU mL(-1) and > = 4.02 kU mL(-1) as cutoffs, the sensitivities, specificities, accuracies for predicting significant necro-inflammation and significant fibrosis were 0.929, 0.964, 0.952 and 1.000, 1.000, 1.000, respectively. These results indicated favorable performances of serum HBcrAg for predicting severe necro-inflammation and advanced fibrosis in HBeAg-positive patients and significant necro-inflammation and significant fibrosis in negative patients. (C) 2016 Elsevier B.V. All rights reserved.