Supplementation with gum arabic fiber increases fecal nitrogen excretion and lowers serum urea nitrogen concentration in chronic renal failure patients consuming a low-protein diet
Supplementation with gum arabic fiber increases fecal nitrogen excretion and lowers serum urea nitrogen concentration in chronic renal failure patients consuming a low-protein diet
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DOI：
10.1093/ajcn/63.3.392
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发表时间：
1996-03-01
影响因子：
7.1
通讯作者：
Settle, RG
中科院分区：
文献类型：
--
作者：
Bliss, DZ;Stein, TP;Settle, RG
在慢性肾衰竭（CRF）中，蛋白质代谢产物的血浆浓度增加。目前的饮食管理是规定减少蛋白质摄入量。使用膳食纤维增加CRF中残留代谢物的饲料排泄可能是低蛋白饮食（LPD）的有益辅助。结肠细菌发酵膳食纤维，为它们提供生长和氮结合的能量，反过来，增加粪便中的氮排泄。在一项前瞻性、单盲、交叉设计中，16名服用LPD的CRF患者被随机分配接受高发酵纤维、阿拉伯树胶（50 g/d）或安慰剂（1 g果胶/d）的补充。与基线LPD或补充果胶相比，补充阿拉伯树胶期间粪便细菌量和粪便氮含量显著增加。与基线LPD或补充果胶相比，补充阿拉伯树胶期间血清尿素氮显著降低。氮平衡没有明显变化。
In chronic rend failure (CRF), plasma concentrations of the products of protein metabolism are increased. Current dietary management is to prescribe a decrease in protein intake. The use of dietary fiber to increase feed excretion of retained metabolites in CRF may be a beneficial adjunct to a low-protein diet (LPD). Colonic bacteria ferment dietary fiber, providing them with energy for growth and nitrogen incorporation, in turn, increasing nitrogen excretion in feces. Sixteen CRF patients consuming an LPD were randomly assigned to receive a supplement of a highly fermentable fiber, gum arabic (50 g/d), or a placebo (1 g pectin/d) in a prospective, single-blind, crossover design. Fecal bacterial mass and fecal nitrogen content were significantly increased during supplementation with gum arabic compared with the baseline LPD or supplementation with pectin. Serum urea nitrogen was significantly decreased during supplementation with gum arabic compared with the baseline LPD or supplementation with pectin. Nitrogen balance did not change significantly.