Presynaptic dopaminergic function in the striatum of schizophrenic patients
Presynaptic dopaminergic function in the striatum of schizophrenic patients
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DOI：
10.1016/s0920-9964(96)00102-8
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发表时间：
1997-02-07
影响因子：
4.5
通讯作者：
Martinot, JL
中科院分区：
文献类型：
--
作者：
DaoCastellana, MH;PaillereMartinot, ML;Martinot, JL
精神分裂症的多巴胺能假说假定大脑多巴胺能活动增强。先前的两项研究报告称，通过正电子发射断层扫描发现精神分裂症患者（分别为n = 5和n = 7）对F - 18 - 多巴的摄取增加。在本研究中，对6名未接受治疗的精神分裂症患者和7名年龄及性别相当的对照受试者进行了体内纹状体多巴胺能功能评估。利用配准的正电子发射断层扫描和磁共振成像确定了尾状核和壳核中F - 18 - 氟 - L - 多巴（F - 18 - 多巴）摄取速率常数Ki。未发现两组之间平均Ki存在差异。尾状核中F - 18 - 多巴摄取值的变异性较高（p（此处似乎内容不完整）
The dopaminergic hypothesis of schizophrenia postulates increased brain dopaminergic activity. Two previous studies reported increased F-18-DOPA uptake with positron emission tomography in schizophrenic patients (n=5, n=7). In the present study, striatal dopaminergic function was assessed in vivo in six untreated schizophrenics and seven control subjects, comparable for age and sex. The F-18-fluoro-L-DOPA (F-18-DOPA) uptake rate constant K-i was determined in the caudate and putamen using coregistered positron emission tomography and magnetic resonance imaging. No difference between groups for mean K-i was found. The variability of the F-18-DOPA uptake values was higher in the caudate (p