On the measurement of multi-component T2 relaxation in cartilage by MR spectroscopy and imaging
On the measurement of multi-component T2 relaxation in cartilage by MR spectroscopy and imaging
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DOI：
10.1016/j.mri.2009.12.006
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发表时间：
2010-05-01
影响因子：
2.5
通讯作者：
Xia, Yang
中科院分区：
文献类型：
--
作者：
Zheng, ShaoKuan;Xia, Yang
采用Carr-Purcell-Meiboom-Gill（CPMG）序列的核磁共振波谱和CPMG-SE成像序列的显微磁共振成像（mu MRI）方法研究了牛鼻软骨（BNC）的多组分T-2松弛。所有实验数据均采用非负最小二乘法（NNLS）进行分析。两种实验方法均发现BNC中只有一种T-2组分（胰蛋白酶酶解前后分别为113和170 ms）。在这项研究中，研究了几个实验和与药物相关的因素，发现其中一些因素可以产生人工多组分T-2，包括在某些成像梯度下使用标准MSME成像序列。(C)2010年爱思唯尔公司All rights reserved.
The multicomponent T-2 relaxation in bovine nasal cartilage (BNC) was investigated by nuclear magnetic resonance spectroscopy using the Carr-Purcell-Meiboom-Gill (CPMG) sequence and microscopic magnetic resonance imaging (mu MRI) method using a CPMG-SE imaging sequence. All experimental data were analyzed by the non-negative least square (NNLS) procedure. Only one T-2 component was found in BNC by both experimental methods (about 113 and 170 ms before and after being enzymatically digested by trypsin). Several experimental and specimen-related factors were investigated in this study, and it was found that some of them could produce artificial multi-component T-2, including the use of the standard MSME imaging sequence at certain imaging gradients. (C) 2010 Elsevier Inc. All rights reserved.