Smoking as a risk factor for cystoid macular edema complicating intermediate uveitis
Smoking as a risk factor for cystoid macular edema complicating intermediate uveitis
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DOI：
10.1016/j.ajo.2007.12.032
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发表时间：
2008-05-01
影响因子：
4.2
通讯作者：
Dunn, James P.
中科院分区：
文献类型：
--
作者：
Thorne, Jennifer E.;Daniel, Ebenezer;Dunn, James P.
目得：描述中间葡萄膜炎患者黄斑囊样水肿（CME）存在的危险因素。设计：横断面研究。方法：设置：单中心，学术实践。研究人群：从1984年7月1日至2006年9月30日评估了208例中间葡萄膜炎患者。程序：将临床和人口统计学数据回顾性输入数据库并进行分析。结局指标：CME的存在，在介绍给我们的诊所，风险因素与CME.RESULTS：在208例患者中，74%有双边中间葡萄膜炎，产生363受影响的眼睛。80，9例患者（43%）在我们的诊所就诊时至少有一只眼睛患有CME。在控制了包括人口统计学、病程、活动性眼内炎症、糖尿病或高血压史、视网膜前膜存在等潜在混杂变量后，就诊时主动吸烟与就诊时CME风险增加4倍相关。（比值比（OR），3.90; 95%置信区间（CI），1.43，10.66; P = 0.008）。在多变量分析中，既往吸烟似乎也会增加CME的风险，但结果具有边缘统计学意义（OR，1.97; 95%CI，0.99，3-94; P = 0.055）。调整混杂因素后，每天每吸一支烟，CME的风险增加4%（OR，1.04; 95%CI，1.01，1.7; P = 0.005）。结论- CME是我们队列中观察到的常见眼部结构并发症。目前吸烟与剂量相关，依赖性增加的风险有CME在我们的诊所提出的时间。
PURPOSE: To describe risk factors for the presence of cystoid macular edema (CME) among patients presenting with intermediate uveitis.DESIGN: Cross-sectional study.METHODS: SETTINGS: Single,center, academic practice. STUDY POPULATION: Two hundred and eight patients with intermediate uveitis evaluated from July 1, 1984 through September 30, 2006. PROCEDURES: Clinical and demographic data were entered retrospectively into a database and analyzed. OUTCOME MEASURES: Presence of CME at presentation to our clinic; risk factors for presenting with CME.RESULTS: Of the 208 patients, 74% had bilateral intermediate uveitis, yielding 363 affected eyes. Eighty, nine patients (43%) had CME in at least one eye at the time of presentation to our clinic. After controlling for potentially confounding variables including demographics, duration of disease, active intraocular inflammation, history of diabetes mellitus or hypertension, and presence of epiretinal membrane, actively smoking at presentation was associated with a four-fold increased risk of CME at presentation vs never smoking (odds ratio (OR), 3.90; 95% confidence interval (CI), 1.43, 10.66; P = .008) . Former smoking also appeared to increase the risk of CME at presentation in the multivariate analysis, but the result was of borderline statistical significance (OR, 1.97; 95% CI, 0.99, 3-94; P = .055). After adjusting for confounding, there was a 4% increased risk of CME at presentation for each cigarette smoked per day (OR, 1.04; 95% CI, 1.01, 1.7; P = .005).CONCLUSIONS- CME was a common structural ocular complication observed in our cohort. Current smoking was associated with a dose,dependent increased risk of having CME at the time of presentation to our clinic.