Application of (4+3) cycloaddition strategies in the synthesis of natural products
Application of (4+3) cycloaddition strategies in the synthesis of natural products
复制标题
(4 3)环加成策略在天然产物合成中的应用
DOI：
10.1039/c8cs00532j
复制
发表时间：
2018
影响因子：
46.2
通讯作者：
Pauline Chiu
中科院分区：
文献类型：
--
作者：
Zengsheng Yin;Yun He;Pauline Chiu
（4+3）环加成反应在合成中有着广泛的应用，本文综述了近年来（4+3）环加成反应在天然产物合成中的应用，包括形式（4+3）环加成反应。这些天然产物靶框架中的许多具有环庚烷亚基，对于这些亚基，（4+3）环加成是它们组装的收敛策略。一些天然产物目标不具有七元环，并且它们的合成利用了由这些反应产生的赋予官能团的（4+3）环加合物，突出了这种方法用于合成一系列复杂分子的效用。
(4+3) Cycloadditions have been widely applied in synthesis, and in this review article, we summarize some of the more recent applications, including formal (4+3) cycloadditions, in the synthesis of natural products. Many of these natural product target frameworks have cycloheptane subunits, for which the (4+3) cycloaddition is a convergent strategy for their assembly. Some natural product targets do not possess seven membered rings, and their syntheses have exploited the functional group endowed (4+3) cycloadducts resulting from these reactions, highlighting the utility of this methodology for the synthesis of a range of complex molecules.