SMOKING WITHOUT NICOTINE DELIVERY DECREASES WITHDRAWAL IN 12-HOUR ABSTINENT SMOKERS
SMOKING WITHOUT NICOTINE DELIVERY DECREASES WITHDRAWAL IN 12-HOUR ABSTINENT SMOKERS
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DOI：
10.1016/0091-3057(94)00269-o
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发表时间：
1995-01-01
影响因子：
3.6
通讯作者：
PICKWORTH, WB
中科院分区：
文献类型：
--
作者：
BUTSCHKY, MF;BAILEY, D;PICKWORTH, WB
感官因素对吸烟满意度和尼古丁戒断症状的贡献通过评估对三种类型香烟的反应来评估：普通香烟、去尼古丁香烟（de-nic）和生菜叶香烟。通过要求受试者使用五端口香烟歧管吸烟来改变剂量。普通香烟或去尼古丁香烟与生菜香烟的比率在以下值范围内变化：0、1、2和4/5。7名男性吸烟者在测试前被剥夺烟草12小时。在一个测试日，他们抽去尼克香烟，在另一天，他们抽普通香烟。满意度和香烟喜好的评级与常规或非常规香烟的数量直接相关，但在常规香烟之后通常更高。普通香烟和非尼克香烟在减轻急性戒断症状方面相当。两个实验日的过期CO相似。普通香烟剂量依赖性地增加血浆烟碱，而去尼克香烟不增加血浆烟碱。这些结果表明，香烟的感官特性有助于吸烟传递尼古丁的滥用倾向。结果表明，吸烟不提供尼古丁的香烟可能会暂时抑制香烟戒断症状。
The contribution of sensory factors to smoking satisfaction and nicotine withdrawal symptoms was assessed by evaluating responses to three types of cigarettes: a regular cigarette, a de-nicotinized cigarette (de-nic), and a lettuce leaf cigarette. Doses were varied by requiring subjects to smoke cigarettes using a five-port cigarette manifold. The ratio of the regular or de-nic cigarettes to the lettuce cigarettes was varied across the following values: zero, one, two, and four of five. Seven male smokers were tobacco-deprived for 12 h before testing. On one test day they smoked the de-nic cigarettes, and on another day they smoked the regular cigarettes. Ratings of satisfaction and cigarette liking were directly related to the number of regular or de-nic cigarettes, but were generally higher after the regular cigarette. The regular and de-nic cigarettes were equivalent in reducing acute withdrawal symptoms. Expired CO was similar on both experimental days. The regular cigarette dose-dependently increased plasma nicotine, but the de-nic cigarette did not increase plasma nicotine. These results indicate that sensory characteristics of cigarettes contribute to the abuse liability of smoke-delivered nicotine. The results suggest that smoking cigarettes that do not provide nicotine may temporarily suppress cigarette withdrawal symptoms.