Effects of topical dorzolamide on IOP after phacoemulsification with different types of ophthalmic viscosurgical devices
Effects of topical dorzolamide on IOP after phacoemulsification with different types of ophthalmic viscosurgical devices
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DOI：
10.1177/112067210701700106
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发表时间：
2007-01-01
影响因子：
1.7
通讯作者：
Simsek, S.
中科院分区：
文献类型：
--
作者：
Altintas, A. G. Kocak;Anayol, M. A.;Simsek, S.
目的.目的评价多佐胺对不同类型眼用粘弹剂（OVD）常规超声乳化白内障吸除术后眼压的影响。拟行白内障超声乳化联合人工透镜（IOL）植入术的患者平均分为4组。组I（83只眼）术后立即接受1滴局部多佐胺，并在IOL植入期间使用1.4% NaHa（BD Visc（R））作为粘性OVD。Ⅱ组（83眼）术后不使用任何抗青光眼药物，使用1.4%NaHa作为粘性OVD。III组（83只眼）局部使用多佐胺并使用1% NaHa（Healon（R）），IV组（83只眼）不使用任何局部药物并在手术中使用1% NaHa。比较两组的平均术后IOP。使用1.4% NaHa的眼睛（18.2 ± 9.2 mmHg）的平均术后IOP高于使用1% NaHa的眼睛（15.5 ± 5.3 mmHg）（p=0.002）。在使用1.4% NaHa和1% NaHa的眼睛中，使用多佐胺的眼睛的平均术后IOP（15.6 ± 7.2 mmHg）低于未使用任何药物的眼睛（18.1 ± 8.5 mmHg）（p=0.003）。多佐胺的应用导致两组的平均术后IOP平均降低2.5 mmHg。OVD对白内障超声乳化术后眼压升高的影响与其分子结构密切相关。粘度增加导致术后IOP增量增加。然而，局部应用多佐胺可有效降低使用Healon（R）和BD Visc（R）的眼睛的术后IOP增量。
PURPOSE. TO evaluate the effect of topical dorzolamide on postoperative intraocular pressure (IOP) after routine phacoemulsification surgery with different type of ophthalmic viscosurgical device (OVD).METHODS. Patients who were scheduled for phacoemulsification with intraocular lens (IOL) implantation were evenly divided into four groups. Group I (83 eyes) received one drop of topical dorzolamide immediately after surgery and 1.4% NaHa (BD Visc (R)) was used as a cohesive OVD during IOL implantation. Group II (83 eyes) did not receive any topical antiglaucoma medication after operation and 1.4% NaHa was used as a cohesive OVD. Group III (83 eyes) received topical dorzolamide and 1% NaHa (Healon (R)) was used, and Group IV (83 eyes) did not receive any topical and 1% NaHa was used in operation. Mean postoperative IOPs were compared between groups.RESULTS. Eyes with 1.4% NaHa usage (18.2 +/- 9.2 mmHg) had higher mean postoperative IOPs than eyes with 1% NaHa usage (15.5 +/- 5.3 mmHg) (p=0.002). Mean postoperative IOPs were lower in eyes with dorzolamide application (15.6 +/- 7.2 mmHg) than in eyes without any medication (18.1 +/- 8.5 mmHg) both in eyes with 1.4% NaHa and 1% NaHa usage (p=0.003). Dorzolamide application caused an average 2.5 mmHg decrease in mean postoperative IOPs in both groups.CONCLUSIONS. Effects of OVDs on IOP rises after phacoemulsification surgery are closely related to their molecular structure. Increase in viscosity rendered higher postoperative IOP increments. However, topical dorzolamide application effectively reduced postoperative IOP increments in eyes with both Healon (R) and BD Visc (R) use.