Dynamic supraparticles for the treatment of age-related diseases
Dynamic supraparticles for the treatment of age-related diseases
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动态超粒子治疗年龄相关疾病
DOI：
10.1016/j.scib.2019.08.003
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发表时间：
2019-12-30
期刊：
影响因子：
18.9
通讯作者：
Ling, Daishun
中科院分区：
文献类型：
--
作者：
Liao, Hongwei;Liang, Zeyu;Ling, Daishun
在我们快速老龄化的社会中，艾滋病相关疾病（ARDs）正在成为公共卫生的主要威胁。目前纳米医学的发展，通过改善药物输送和药物控释，引发了对ARDs管理的乐观情绪。然而，由于ARDs的病理学特征复杂，包括多因素发病机制、复杂的疾病微环境和动态的症状表现，目前对ARDs如癌症和阿尔茨海默病（AD）的有效治疗仍然缺乏。近年来，动态超微粒子（DS），这是可逆的自组装功能纳米粒子，提供了一个新的战略，打击ARDs。除了包括多功能和多靶点在内的纳米医学的固有优势外，DS还能够在某些刺激下进行动态结构重构，创造另一层可操作性，允许对进展和治疗期间ARDs的时空变化进行程序化反应。在这篇综述中，我们将概述ARDs管理所面临的挑战，并讨论DS带来的独特机遇。然后，我们将总结用于ARDs治疗的DS的设计合成。最后，我们将剖析在ARDs的治疗靶点，可以利用DS，并提出了令人鼓舞的进展，在这一领域。希望本文的综述能为我们对DS和ARDs治疗设计原则的认识提供一个桥梁，这可能会启发未来开发有效的治疗诊断剂，以改善医疗保健。(C)中国科学出版社.爱思唯尔公司、科学中国出版社出版。All rights reserved.
Age-related diseases (ARDs) are arising as a major threat to public health in our fast-aging society. Current development of nanomedicine has sparked much optimism toward ARDs management by improving drug delivery and controlled drug release. However, effective treatments for ARDs, such as cancer and Alzheimer's diseases (AD), are still lacking, due to the complicated pathological features of ARDs including multifactorial pathogenesis, intricate disease microenvironment, and dynamic symptom manifestation. Recently, dynamic supraparticles (DS), which are reversibly self-assembled functional nanoparticles, have provided a novel strategy for combating ARDs. Besides the intrinsic advantages of nanomedicine including multifunctional and multitarget, DS are capable of dynamic structural reconfiguration upon certain stimulation, creating another layer of maneuverability that allows programmed response to the spatiotemporal alterations of ARDs during progression and treatment. In this review, we will overview the challenges faced by ARDs management, and discuss the unique opportunities brought by DS. Then, we will summarize the designed synthesis of DS for ARDs treatment. Finally, we will dissect the therapeutic targets in ARDs that can be exploited by DS, and present the encouraging advances in this field. Hopefully, this review will bridge our knowledge of the design principle of DS and ARDs management, which may inspire the future development of potent theranostic agents to improve the healthcare. (C) 2019 Science China Press. Published by Elsevier B.V. and Science China Press. All rights reserved.