Iron as a Drug and Drug-Drug Interactions
Iron as a Drug and Drug-Drug Interactions
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DOI：
10.1007/978-1-59745-462-9_5
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发表时间：
2010-01-01
期刊：
影响因子：
--
通讯作者：
Lewis, Teresa V.
中科院分区：
文献类型：
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作者：
Hagemann, Tracy M.;Lewis, Teresa V.
在抗坏血酸等还原剂的存在下，口服铁的生物利用度可以提高。所有商用的铁盐都能有效地治疗铁缺乏。口服铁的服用应该至少与其他药物分开1-2小时。与其他静脉注射铁制剂相比，使用右旋糖苷铁并不吸引人，因为它有副作用。输注相关的副作用，如低血压，可以通过减缓静脉注射铁制剂的速度来缓解。急性铁中毒应及时进行洗胃和支持性护理。慢性铁中毒可导致严重的器官损害，可用去铁胺、去铁胺和去铁铁等螯合剂治疗。
Bioavailabiltiy of oral iron may be enhanced in the presence of reducing agents such as ascorbic acid.All commercially available iron salts are effective in the treatment of iron deficiency.Administration of oral iron should be separated from other medications by at least 1-2 hours.The use of iron dextran is not attractive compared to other IV iron preparations because of its side effect profile.Infusion-related side effects such as hypotension can be alleviated by slowing the rate of administration of IV iron preparations.Acute iron toxicity should be treated promptly with gastric lavage and supportive care.Chronic iron toxicity can result in significant organ damage and is treated with chelation agents such as deferoxamine, deferiprone, and deferasirox.