Evidence for production by the liver of two IGF binding proteins with similar molecular weights but different affinities for IGF I and IGF II. Their relations with serum and cerebrospinal fluid IGF binding proteins.
Evidence for production by the liver of two IGF binding proteins with similar molecular weights but different affinities for IGF I and IGF II. Their relations with serum and cerebrospinal fluid IGF binding proteins.
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肝脏产生两种 IGF 结合蛋白的证据，它们具有相似的分子量，但对 IGF I 和 IGF II 的亲和力不同。
DOI：
10.1210/jcem-55-3-600
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
P. Hossenlopp
中科院分区：
文献类型：
--
作者：
M. Binoux;Sylvie Hardouin;C. Lassarre;P. Hossenlopp
IGF I和IGF II和125 I标记的IGF I和IGF II与培养物中肝脏产生的特异性结合蛋白（BP）的竞争性结合的研究表明，存在两种BP，一种对IGF I具有选择性亲和力，另一种对IGF II具有选择性亲和力。前者与后者的比例似乎在幼鼠肝和人胎肝的培养液中高于成人肝的培养液中。这两种BP与其IGFs形成具有相同表观分子量约40 K的复合物。用成人血清凝胶过滤，两种类型的BP用大于100 K和40- 70 K分子量的材料洗脱。在40- 70 K材料以及成年人受试者的脑脊液中，对IGF II具有选择性亲和力的BP占主导地位。
Studies of the competitive binding of IGF I and IGF II and 125I-labelled IGF I and IGF II to the specific binding proteins (BPs) produced by the liver in culture suggest that two BPs exist, one with a selective affinity for IGF I and the other with a selective affinity for IGF II. The ratio of the former BP to the latter appeared to be higher in the culture medium of young rat livers and of fetal human livers than that in the culture medium of adult human livers. The two BPs form complexes with their IGFs with the same apparent molecular weight of approximately 40K. With gel filtration of adult human serum both types of BP eluted with the greater than 100K and the 40-70K molecular weight material. The BP with the selective affinity for IGF II predominated in the 40-70K material as well as in the cerebrospinal fluid of adult human subjects.
垂体功能减退症中的血浆生长调节素结合蛋白：生长激素治疗期间的变化。
DOI：
10.1210/jcem-53-1-100
发表时间：
1981
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
Hintz,RL;Liu,F;Rosenfeld,RG;Kemp,SF
通讯作者：
Kemp,SF