Neural correlates of performance variability during motor sequence acquisition
Neural correlates of performance variability during motor sequence acquisition
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DOI：
10.1016/j.neuroimage.2011.12.049
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发表时间：
2012-03-01
期刊：
影响因子：
5.7
通讯作者：
Maquet, Pierre
中科院分区：
文献类型：
--
作者：
Albouy, Genevieve;Sterpenich, Virginie;Maquet, Pierre
在运动序列的初始训练期间，性能逐渐变得更快，但也越来越可重复性和一致性。然而，在训练中期，表现暂时变得更加多变，反映了运动表征的变化和最终选择最佳表现模式(Adi-Japha等人，2008年)。在大脑水平上，虽然已知操作速度与小脑-皮质和纹状体-皮质网络的活动有关，但操作变异性的神经关联仍不清楚。在手指敲击任务(M)的初始训练中，我们使用功能磁共振成像(FMRI)来表征后者，在此过程中，参与者用左手非优势手在键盘上产生一个由5个元素组成的手指序列。我们的结果表明，随着操作的更加一致，楔前核中的反应减少，而尾状核中的反应增加。此外，不同的表现与海马区和额顶区以及纹状体和额区之间的相互作用增强有关。我们的结果表明，这些动态的大规模相互作用是在人类中实现一致运动行为的基石。(C)2012 Elsevier Inc.保留所有权利。
During the initial training of a motor sequence, performance becomes progressively faster but also increasingly reproducible and consistent. However, performance temporarily becomes more variable at mid-training, reflecting a change in the motor representation and the eventual selection of the optimal performance mode (Adi-Japha et al., 2008). At the cerebral level, whereas performance speed is known to be related to the activity in cerebello-cortical and striato-cortical networks, the neural correlates of performance variability remain unknown. We characterized the latter using functional magnetic resonance imaging (fMRI) during the initial training to the Finger Tapping Task (M), during which participants produced a 5-element finger sequence on a keyboard with their left non-dominant hand. Our results show that responses in the precuneus decrease whereas responses in the caudate nucleus increase as performance becomes more consistent. In addition, a variable performance is associated with enhanced interaction between the hippocampus and fronto-parietal areas and between the striatum and frontal areas. Our results suggest that these dynamic large-scale interactions represent a cornerstone in the implementation of consistent motor behavior in humans. (C) 2012 Elsevier Inc. All rights reserved.