Chiral Separation of a Racemic Compound Induced by Transformation of Racemic Crystal Structures: dl-Glutamic Acid
Chiral Separation of a Racemic Compound Induced by Transformation of Racemic Crystal Structures: dl-Glutamic Acid
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DOI：
10.1021/cg050579i
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发表时间：
2006-06
影响因子：
3.8
通讯作者：
M. Yokota;N. Doki;K. Shimizu
中科院分区：
文献类型：
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作者：
M. Yokota;N. Doki;K. Shimizu
我们发现，一个适当的添加剂（L-Arg）诱导结晶的DL-谷氨酸（DL-Glu）作为对映体纯晶体的混合物，即使在条件下，外消旋晶体（两个对映体在晶胞）通常结晶从纯系统。此外，该添加剂成功地延迟了对映异构体之一（l-Glu）的结晶。在此基础上，提出了用手性添加剂将外消旋晶体动力学拆分成其组成对映体的方法。
We found that an appropriate additive (l-Arg) induced the crystallization of dl-glutamic acid (dl-Glu) as a mixture of enantiomerically pure crystals, even under conditions where racemic crystals (both enantiomers in the unit cell) normally crystallize from the pure system. In addition, the additive successfully delayed the crystallization of one of the enantiomers (l-Glu). On the basis of these results, kinetic resolution of racemic crystals into their constituent enantiomers by a chiral additive is proposed.