The many postures of noncanonical Wnt signaling in development and diseases.
The many postures of noncanonical Wnt signaling in development and diseases.
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DOI：
10.1016/j.biopha.2017.06.061
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发表时间：
2017-09
期刊：
影响因子：
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通讯作者：
Qian Xiao;Zhengxi Chen;Xiaozhuang Jin;Runyi Mao;Zhen-qing Chen
中科院分区：
文献类型：
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作者：
Qian Xiao;Zhengxi Chen;Xiaozhuang Jin;Runyi Mao;Zhen-qing Chen
Wnt signaling regulates many aspects of vertebrate development. Its dysregulation causes developmental defects and diseases including cancer. The signaling can be categorized in two pathways: canonical and noncanonical. Canonical pathway plays a key role in regulating proliferation and differentiation of cells whilst noncanonical Wnt signaling mainly controls cellular polarity and motility. During development, noncanonical Wnt signaling is required for tissue formation. Recent studies have shown that noncanonical Wnt signaling is involved in adult tissue development and cancer progression. In this review, we try to describe and discuss the mechanisms behind the biological effects of noncanonical Wnt signaling, diseases caused by its dysregulation, and implications in adult tissue development biology.
