Birthweight of full-term infants is associated with cord blood CD34+ cell concentration
Birthweight of full-term infants is associated with cord blood CD34+ cell concentration
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DOI：
10.1080/08035250410033060
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发表时间：
2004-10-01
期刊：
影响因子：
3.8
通讯作者：
Kekomäki, R
中科院分区：
文献类型：
--
作者：
Aroviita, P;Teramo, K;Kekomäki, R
目的：CD34(+) 细胞计数用于确定给定脐带血移植物的造血干细胞潜力。目的是检验这样的假设：高浓度的脐带血造血祖细胞和干细胞可能反映了宫内生长，而出生体重是宫内生长的一个指标。方法：应用简单和多元回归分析来测试 1368 名婴儿的脐带血库数据，以确定选定的产科因素与脐带血细胞含量之间的关联。结果：当根据给定变量的极值（第 5 个百分位数与第 95 个百分位数）形成分组时，例如出生体重，出生体重最高的足月婴儿被发现具有统计学上显着较高的中位脐带血 CD34(+) 细胞浓度。此外，相对出生体重前 50% 的婴儿的 CD34(+) 细胞浓度中位数高于相对出生体重后 50% 的婴儿。在多元回归分析中，出生体重和CD34(+)细胞浓度之间的相关性具有明显的统计学意义。值得注意的是，虽然发现胎龄和有核细胞浓度之间存在预期的相关性，但婴儿胎龄和 CD34(+) 细胞浓度之间没有相关性。结论：造血祖细胞和干细胞可能反映宫内生长，并且在胎儿发育中比之前报道的更重要。
Aim: CD34(+) cell counts are used to define the haematopoietic stem cell potential of a given cord blood transplant. The aim was to test the hypothesis that high concentration of cord blood haematopoietic progenitor and stem cells could be a reflection of intrauterine growth, of which birthweight is an indicator. Methods: Simple and multiple regression analyses were applied to test cord blood bank data on 1368 infants for associations of selected obstetric factors and cellular contents of cord blood. Results: When groups were formed based on the extreme values (5th versus 95th percentiles) of a given variable, e.g. birthweight, the term infants having the highest birthweights were found to have statistically significantly higher median cord blood CD34(+) cell concentrations. Also, infants in the top 50th percentile of relative birthweight had higher median CD34(+) cell concentration than infants in the low 50th percentile. In multiple regression analysis, the correlation between birthweight and CD34(+) cell concentration was statistically clearly significant. Notably, while an expected correlation between gestational age and nucleated cell concentration was found, there was no association between infant gestational age and CD34(+) cell concentration.Conclusion: Haematopoietic progenitor and stem cells may reflect intrauterine growth and have a more central role in foetal development than has been reported earlier.