Correlation Between Dosimetric Parameters and Acute Dermatitis of Post-operative Radiotherapy in Breast Cancer Patients
Correlation Between Dosimetric Parameters and Acute Dermatitis of Post-operative Radiotherapy in Breast Cancer Patients
复制标题
DOI：
10.21873/invivo.11406
复制
发表时间：
2018-11-01
期刊：
影响因子：
2.3
通讯作者：
Yamada, Kei
中科院分区：
文献类型：
--
作者：
Takenaka, Tadashi;Yamazaki, Hideya;Yamada, Kei
背景/目的：研究早期乳腺癌术后放疗患者剂量学参数与急性放射性皮炎的相关性。患者与方法：对84例术后放疗患者的资料进行分析。处方总剂量为50戈伊，分25次，5周。根据不良事件通用术语标准v4.0评估放射性皮炎。我们将整个身体（通过CT图像检查的从颈部到腹部）的危险器官也设置为替代皮肤体积（3 mm厚度）。结果：共有28例患者在50戈伊时间点表现出放射性皮炎等级等于或高于2级。将这28名患者与同一治疗期间患有0-1级放射性皮炎的56名配对患者进行比较。患者整体体积的V5-20和V40以及皮肤体积的V40-50的平均值在出现≥ 2级急性放射性皮炎的患者中显著高于其他未出现急性放射性皮炎的患者。观察到V40皮肤体积和VS患者整体体积的统计学最显著差异。VS（全身）>1,360 cm（3）的患者急性放射性皮炎≥ 2级的发生率显著高于VS（全身）45 cm（3）的患者，而V40（皮肤体积）= 2的患者则显著高于VS（全身）45 cm（3）的患者。VS（全身）1,360 cm（3）和V40（皮肤体积）45 cm（3）可能是≥ 2级放射性皮炎的剂量体积限制。
Background/Aim: To examine the correlation between dosimetric parameters and acute radiation dermatitis in early breast cancer patients subjected to post-operative radiotherapy. Patients and Methods: The data of 84 patients treated with post-operative radiotherapy were analyzed. The total prescribed dose was 50 Gy in 25 fractions over 5 weeks. Radiation dermatitis was assessed according to Common Terminology Criteria for Adverse Events v4.0. We set organ at risk whole body (from neck to abdomen examined by CT images) also as surrogate skin volume (3 mm thickness). Results: A total of 28 patients showed radiation dermatitis grade equal or higher than 2 at the 50 Gy time point. These 28 patients were compared to 56 matched pair patients with grade 0-1 radiation dermatitis during the same treatment period. The mean of V5-20 and V40 in patient's whole volume and V40-50 in skin volume were significantly higher in patients who presented with acute radiation dermatitis Grades >= 2 than in the other patients who did not. The statistically most significant difference was observed for V40 for skin volume and VS for patient whole volume. Rate of acute radiation dermatitis grade >= 2 was significantly higher for patients with VS (whole body) >1,360 cm(3) than those with VS (whole body) 45 cm(3) compared with those with V40 (skin volume) = 2. VS (whole body) 1,360 cm(3) and V40 (skin volume) 45 cm(3) may be dose volume constrain for radiation dermatitis grade >= 2.