THE CONSORTIUM TO ESTABLISH A REGISTRY FOR ALZHEIMERS-DISEASE (CERAD) .11. CLINICAL MILESTONES IN PATIENTS WITH ALZHEIMERS-DISEASE FOLLOWED OVER 3 YEARS
THE CONSORTIUM TO ESTABLISH A REGISTRY FOR ALZHEIMERS-DISEASE (CERAD) .11. CLINICAL MILESTONES IN PATIENTS WITH ALZHEIMERS-DISEASE FOLLOWED OVER 3 YEARS
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DOI：
10.1212/wnl.45.8.1451
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发表时间：
1995-08-01
期刊：
影响因子：
9.9
通讯作者：
KOSS, E
中科院分区：
文献类型：
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作者：
GALASKO, D;EDLAND, SD;KOSS, E
通过心理测量测试测量的认知能力下降的速度被广泛用于跟踪阿尔茨海默病（AD）的进展。作为一种替代方法，我们研究了343名社区居住的可能患有AD的患者的临床指标，这些患者参加了多中心联盟建立阿尔茨海默病登记处（CERAD）项目。受试者在入组和年度随访时接受标准化评估。临床痴呆评分下降、工具性日常生活活动丧失、在简易精神状态检查（MMSE）中无法回忆三个单词以及MMSE总分下降至10分以下是高风险里程碑，3年时累积频率超过50%。穿衣和排便活动的损失发生在中等速度，而进食能力的损失是罕见的。达到临床里程碑的风险和MMSE认知能力下降的年发生率直接相关。临床里程碑是AD患者痴呆进展的有用指标。
The rate of cognitive decline, measured by psychometric testing, is widely used to track the progression of Alzheimer's disease (AD). As an alternative approach, we studied clinical measures as markers of the progression of dementia in 343 community-dwelling patients with probable AD enrolled in the multi-center Consortium to Establish a Registry for Alzheimer's Disease (CERAD) project. Subjects received standardized evaluations at entry and at annual follow-up. Decline on the Clinical Dementia Rating, loss of instrumental activities of daily living, failure to recall three words on the Mini-Mental State Examination (MMSE), and decline of the total MMSE score to below 10 were high-risk milestones, with cumulative frequencies exceeding 50% at 3 years. Loss of dressing and toileting activities occurred at intermediate rates, while loss of eating ability was rare. The risk of reaching clinical milestones and the annual rate of cognitive decline on the MMSE were directly correlated. Clinical milestones are useful indices of the progression of dementia in patients with AD.