Alcohol consumption appears to protect against non-alcoholic fatty liver disease
Alcohol consumption appears to protect against non-alcoholic fatty liver disease
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DOI：
10.1111/j.1365-2036.2010.04520.x
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发表时间：
2011-02-01
影响因子：
7.6
通讯作者：
Yamamoto, K.
中科院分区：
文献类型：
--
作者：
Moriya, A.;Iwasaki, Y.;Yamamoto, K.
背景适度饮酒可能对与代谢综合征相关的非酒精性脂肪性肝病有一定的有益作用。目的探讨日本男性和女性饮酒方式与脂肪肝的关系。方法采用健康体检资料，包括饮酒情况和脂肪肝超声检查资料，进行横断面研究。结果：我们分析了4957名男性和2155名女性，未报告肝脏疾病（中位年龄49岁）。在男性中，40%的不饮酒者和28%的饮酒者患有脂肪肝。饮酒与脂肪肝呈负相关（校正优势比为0.54；95%可信区间为0.46-0.63）。各类饮酒频次中脂肪肝患病率分别为38%（1-3天/周）、29%（4-6天/周）和24%（每日饮酒）；饮酒频率与脂肪肝患病率呈显著负相关（P < 0.001）。在女性中，16%的不饮酒者和10%的饮酒者患有脂肪肝。每周1-3天饮酒量少于20克与脂肪肝患病率低相关（校正优势比为0.47；95%可信区间为0.23-0.96）。结论饮酒可预防非酒精性脂肪肝。
P>BackgroundModerate alcohol consumption may have certain beneficial effects against non-alcoholic fatty liver disease, which is associated with metabolic syndrome.AimTo determine the association between drinking pattern and fatty liver in Japanese men and women.MethodsA cross-sectional study was performed with health checkup data including information concerning alcohol consumption and ultrasonographic assessment of fatty liver.ResultsWe analysed 4957 men and 2155 women without reported liver diseases (median age, 49 years). In men, 40% of nondrinkers and 28% of drinkers had fatty liver. Alcohol consumption was inversely associated with fatty liver (adjusted odds ratio, 0.54; 95% confidence interval, 0.46-0.63). The prevalence of fatty liver in each category of drinking frequency was 38% (1-3 days/week), 29% (4-6 days/week), and 24% (daily drinking); there was a significant inverse correlation between drinking frequency and the prevalence of fatty liver (P < 0.001). In women, 16% of nondrinkers and 10% of drinkers had fatty liver. Drinking less than 20 g on 1-3 days/week was associated with low prevalence of fatty liver (adjusted odds ratio, 0.47; 95% confidence interval, 0.23-0.96).ConclusionsAlcohol consumption appears to protect against non-alcoholic fatty liver disease.