Effects of Gas Exchange on Acid-Base Balance
Effects of Gas Exchange on Acid-Base Balance
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DOI：
10.1002/cphy.c100055
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发表时间：
2012-07-01
影响因子：
5.8
通讯作者：
Heigenhauser, George J. F.
中科院分区：
文献类型：
--
作者：
Lindinger, Michael I.;Heigenhauser, George J. F.
本文描述了通气和酸碱平衡在多种条件下的相互作用，包括休息、运动、海拔、妊娠和各种肌肉、呼吸、心脏和肾脏疾病。我们介绍了评估酸碱状态的物理化学方法，并通过文献中的例子演示了如何使用这种方法来量化酸碱失调的起源。本文总结了化学受体和代谢受体控制通气和酸碱平衡之间的关系，适用于成人、青年和各种病理条件。在影响通气的酸碱平衡紊乱（即运动）和影响酸碱平衡的强加的或病理性的通气紊乱（即运动）之间存在动态的相互作用。通气和酸碱平衡之间的相互作用在中高强度运动、海拔、诱发酸中毒和碱中毒、妊娠、肥胖和一些病理条件下被强调。在许多情况下，缺乏完整的酸碱数据，表明需要进一步研究以阐明酸碱状态改变与通气反应之间关系的机制基础。(C) 2012年美国生理学会。中国生物医学工程学报（英文版），2012。
This paper describes the interactions between ventilation and acid-base balance under a variety of conditions including rest, exercise, altitude, pregnancy, and various muscle, respiratory, cardiac, and renal pathologies. We introduce the physicochemical approach to assessing acid-base status and demonstrate how this approach can be used to quantify the origins of acid-base disorders using examples from the literature. The relationships between chemoreceptor and metaboreceptor control of ventilation and acid-base balance summarized here for adults, youth, and in various pathological conditions. There is a dynamic interplay between disturbances in acid-base balance, that is, exercise, that affect ventilation as well as imposed or pathological disturbances of ventilation that affect acid-base balance. Interactions between ventilation and acid-base balance are highlighted for moderate-to high-intensity exercise, altitude, induced acidosis and alkalosis, pregnancy, obesity, and some pathological conditions. In many situations, complete acid-base data are lacking, indicating a need for further research aimed at elucidating mechanistic bases for relationships between alterations in acid-base state and the ventilatory responses. (C) 2012 American Physiological Society. Compr Physiol 2:2203-2254, 2012.