GENERALIZED OSTEOARTHRITIS ASSOCIATED WITH INCREASED INSULIN-LIKE GROWTH-FACTOR TYPE-I AND TYPE-II AND TRANSFORMING GROWTH-FACTOR-BETA IN CORTICAL BONE FROM THE ILIAC CREST - POSSIBLE MECHANISM OF INCREASED BONE-DENSITY AND PROTECTION AGAINST OSTEOPOROSIS
GENERALIZED OSTEOARTHRITIS ASSOCIATED WITH INCREASED INSULIN-LIKE GROWTH-FACTOR TYPE-I AND TYPE-II AND TRANSFORMING GROWTH-FACTOR-BETA IN CORTICAL BONE FROM THE ILIAC CREST - POSSIBLE MECHANISM OF INCREASED BONE-DENSITY AND PROTECTION AGAINST OSTEOPOROSIS
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DOI：
10.1002/art.1780361209
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发表时间：
1993-12-01
影响因子：
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通讯作者：
BAYLINK, DJ
中科院分区：
文献类型：
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作者：
DEQUEKER, J;MOHAN, S;BAYLINK, DJ
目标。探讨生长因子在骨中的储存是否可能解释广泛性骨关节炎患者骨密度的增加和对骨质疏松症的抵抗。在有或没有手骨关节炎的受试者尸检时获得的髂嵴皮质骨提取物中，测量了胰岛素样生长因子（IGF） I型和II型及转化生长因子β (tgf β)的水平。骨关节炎组骨粉提取物中IGF-I、IGF-II和tgf - β的浓度明显高于对照组。结果表明，骨关节炎患者骨密度的增加和对骨质疏松的抵抗可能与骨骼中IGF-I、IGF-II和tgf - β浓度的增加有关，并且可能反映了这些患者成骨细胞生物合成活性的普遍增加。
Objective. To investigate whether growth factors stored in bone might explain the increased bone density and resistance to osteoporosis in generalized osteoarthritis.Methods. Levels of insulin-like growth factor (IGF) types I and II and transforming growth factor beta (TGFbeta) were measured in extracts of cortical bone from the iliac crest obtained at necropsy from subjects with or without osteoarthritis of the hands.Results. Concentrations of IGF-I, IGF-II, and TGFbeta were significantly higher in extracts of bone powder from subjects in the osteoarthritis group than in extracts from subjects in the control group.Conclusion. The results suggest that the increased bone density and resistance to osteoporosis in patients with osteoarthritis may be associated with increased skeletal concentrations of IGF-I, IGF-II, and TGFbeta and may reflect a generally increased biosynthetic activity of osteoblasts in these patients.