The effect of prolonged exposure of rats to sub-lethal dose of acetaminophen.
The effect of prolonged exposure of rats to sub-lethal dose of acetaminophen.
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大鼠长期暴露于亚致死剂量的对乙酰氨基酚的影响。
DOI：
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发表时间：
1991
期刊：
影响因子：
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通讯作者：
P. Ebong
中科院分区：
文献类型：
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作者：
E. Udosen;P. Ebong
本文研究了雄性白化病大鼠腹腔注射对乙酰氨基酚的亚致死剂量（20 mg、30 mg、100 mg、200 mg和300 mg/Kg体重）和持续时间对pc高铁血红蛋白水平和一些肝功能检查的影响：碱性磷酸酶、游离胆红素和结合胆红素。研究表明，对乙酰氨基酚给药大鼠的pc高铁血红蛋白、游离胆红素和结合胆红素的增加显著（P <0.05）大于对照大鼠，并且测量参数随对乙酰氨基酚浓度增加而增加。结果还表明，游离胆红素可能从血浆白蛋白中置换出来。
In this report, we studied the effect of sub-lethal doses (20mg, 30mg, 100mg, 200mg and 300mg/Kg body weight) and duration of acetaminophen given intraperitoneally (i.p) to male albino rats; on the level of pc methaemoglobin and some liver function tests: Alkaline phosphatase, free and conjugated bilirubin. The study showed that the increase in pc methaemoglobin, free and conjugated bilirubin in rats treated with acetaminophen are significantly (P less than 0.05) greater than those for the control rats and that the measured parameters increase with acetaminophen concentrations. The results also show that the free bilirubin is probably displaced from plasma albumin.