Prediction of Embryotoxicity by Four Kinds of Fluorine Compounds Based on Embryonic Stem Cell Test (EST) Protocol
Prediction of Embryotoxicity by Four Kinds of Fluorine Compounds Based on Embryonic Stem Cell Test (EST) Protocol
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DOI：
10.11223/jarde.14.91
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发表时间：
2016
期刊：
影响因子：
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通讯作者：
K. Imai;H. Oshima;Y. Hashimoto;M. Akiyama;Masayuki Zennyu;Takamitsu Yoshida;T. Nishikawa;K. Masuno;Hidenori Matsumoto
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文献类型：
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作者：
K. Imai;H. Oshima;Y. Hashimoto;M. Akiyama;Masayuki Zennyu;Takamitsu Yoshida;T. Nishikawa;K. Masuno;Hidenori Matsumoto
使用氟化物预防龋齿的安全性一直存在争议。为了明确氟对人胎儿/新生儿胚胎毒性的风险，我们使用Spielmann等人开发的体外胚胎毒性筛选试验EST法，研究了4种氟化物(NaF、KF、SnF2和CuF2)的胚胎毒性水平。1997年。在氟化物中，NaF和SnF2在日本用于预防龋齿。所有物质均“无胚胎毒性”，但SnF2和CuF2接近“弱胚胎毒性”的界限。由于许多年轻人使用氟来预防龋齿，因此需要对氟的胚胎毒性进行进一步的研究。
The safety of fluoride use to prevent dental caries has been controversial. To clarify the risk of embryotoxicity of fluoride influencing human fetuses/newborns, we investigated the embryotoxicity levels of 4 fluorides (NaF, KF, SnF2, and CuF2) using the EST method, which is an in vitro embryotoxicity screening test developed by Spielmann et al. in 1997. Of the fluorides, NaF and SnF2 are used to prevent dental caries in Japan. All substances were" non-embryotoxic", but SnF2 and CuF2 were close to the borderline of" weak embryotoxic". Since many young people use fluoride to prevent dental caries, further investigation of the embryotoxicity of fluorine is desired.