Impact of Cardiovascular Magnetic Resonance Imaging on Identifying the Etiology of Cardiomyopathy in Patients Undergoing Cardiac Transplantation.
Impact of Cardiovascular Magnetic Resonance Imaging on Identifying the Etiology of Cardiomyopathy in Patients Undergoing Cardiac Transplantation.
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DOI：
10.1038/s41598-018-34648-5
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发表时间：
2018-11-01
影响因子：
4.6
通讯作者：
Shenoy C
中科院分区：
文献类型：
--
作者：
Lin LQ;Kazmirczak F;Chen KA;Okasha O;Nijjar PS;Martin CM;Akçakaya M;Farzaneh-Far A;Shenoy C
在进行心脏移植的患者中，已经描述了识别心肌病病因的错误。越来越多的数据表明，心血管磁共振成像（CMR）为心力衰竭提供了独特的诊断信息。我们调查了心脏移植前CMR的表现与确定心肌病病因的错误率的关系。我们比较了移植前的临床诊断和移植后的病理诊断。在338例患者中，有23例（7%）心肌病病因鉴定错误。其中22例（96%）发生在移植前临床诊断为非缺血性心肌病（NICM）的患者中。只有61/338（18%）患者在移植前有cmr。在整个研究队列中，CMR的表现与错误之间没有显著关联（p = 0.093）。在移植前临床诊断为NICM的患者中，CMR的表现与错误之间存在显著的负相关（有和没有CMR的患者分别为2.4%和14.6%,p = 0.030）。总之，CMR在心脏移植前未得到充分利用。在移植前临床诊断为NICM的患者中，96%的患者在确定心肌病病因方面出现了错误，而CMR的表现与更少的错误相关。
Errors in identifying the etiology of cardiomyopathy have been described in patients undergoing cardiac transplantation. There are increasing data that cardiovascular magnetic resonance imaging (CMR) provides unique diagnostic information in heart failure. We investigated the association of the performance of CMR prior to cardiac transplantation with rates of errors in identifying the etiology of cardiomyopathy. We compared pre-transplantation clinical diagnoses with post-transplantation pathology diagnoses obtained from the explanted native hearts. Among 338 patients, there were 23 (7%) errors in identifying the etiology of cardiomyopathy. Of these, 22 (96%) occurred in patients with pre-transplantation clinical diagnoses of non-ischemic cardiomyopathy (NICM). Only 61/338 (18%) had CMRs prior to transplantation. There was no significant association between the performance of CMR and errors in the entire study cohort (p = 0.093). Among patients with pre-transplantation clinical diagnoses of NICM, there was a significant inverse association between the performance of CMR and errors (2.4% vs. 14.6% in patients with and without CMR respectively; p = 0.030). In conclusion, CMR was underutilized prior to cardiac transplantation. In patients with pre-transplantation clinical diagnoses of NICM – in whom 96% of errors in identifying the etiology of cardiomyopathy occurred – the performance of CMR was associated with significantly fewer errors.
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影响因子：
14
作者：
Stacey, R. Brandon;Andersen, Mousumi M.;Thohan, Vinay
通讯作者：
Thohan, Vinay
影响因子：
1.6
作者：
Roberts, William C.;Roberts, Carey Camille;Hall, Shelley Anne
通讯作者：
Hall, Shelley Anne
影响因子：
--
作者：
Valle-Munoz, Alfonso;Estornell-Erill, Jordi;Ridocci-Soriano, Francisco
通讯作者：
Ridocci-Soriano, Francisco
影响因子：
39.3
作者：
McMurray, John J. V.;Adamopoulos, Stamatis;Ponikowski, Piotr
通讯作者：
Ponikowski, Piotr
影响因子：
3.7
作者：
Angelini, A;Boffa, GM;Thiene, G
通讯作者：
Thiene, G