Preoperative butorphanol and flurbiprofen axetil therapy attenuates remifentanil-induced hyperalgesia after laparoscopic gynaecological surgery: a randomized double-blind controlled trial
Preoperative butorphanol and flurbiprofen axetil therapy attenuates remifentanil-induced hyperalgesia after laparoscopic gynaecological surgery: a randomized double-blind controlled trial
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术前布托啡诺和氟比洛芬酯治疗可减轻腹腔镜妇科手术后瑞芬太尼引起的痛觉过敏：一项随机双盲对照试验
DOI：
10.1093/bja/aew248
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发表时间：
2016-10-01
影响因子：
9.8
通讯作者：
Wang, G.
中科院分区：
文献类型：
--
作者：
Zhang, L.;Shu, R.;Wang, G.
Background: Several studies indicate that remifentanil exposure may engender opioid-induced hyperalgesia. Butorphanol and flurbiprofen axetil are proposed as adjunctive analgesics for postoperative pain control. This randomized double-blind controlled study was designed to investigate the antihyperalgesic effects of butorphanol combined with flurbiprofen axetil on opioid-induced hyperalgesia.Methods: One hundred and twenty patients undergoing elective laparoscopic gynaecological surgery with sevoflurane anaesthesia were randomized to one of four groups, as follows: intraoperative sufentanil 0.30 mu g kg(-1) (Group S); remifentanil 0.30 mu g kg(-1) min(-1) (Group R); intraoperative remifentanil and pre-anaesthesia butorphanol 20 mu g kg(-1) (Group B); or intraoperative remifentanil and pre-anaesthesia butorphanol 10 mu g kg(-1) combined with flurbiprofen axetil 0.5 mg kg(-1) (Group BF). Sufentanil was used to control postoperative pain. The threshold and area of postoperative mechanical hyperalgesia were measured with Von Frey filaments. Pain intensity, sufentanil consumption, and side-effects were recorded for 24 h after surgery.Results: Compared with Group S, remifentanil anaesthesia increased the pain score, postoperative sufentanil consumption, and area of hyperalgesia [mean 49.9 (SD 8.6) vs 60.5 (10.0) cm(2), P
