Effect of hyperinsulinemia on myocardial fluorine-18-FDG uptake.
Effect of hyperinsulinemia on myocardial fluorine-18-FDG uptake.
复制标题
高胰岛素血症对心肌氟-18-FDG摄取的影响。
DOI：
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复制
发表时间：
1998
影响因子：
9.3
通讯作者：
P. McNulty
中科院分区：
文献类型：
--
作者：
C. Ng;R. Soufer;P. McNulty
无标签
本研究旨在探讨胰岛素对缺血性心脏病患者心肌18F-脱氧葡萄糖(FDG)和葡萄糖动力学的影响。
方法
12例男性患者(年龄54-79岁，平均年龄69±8岁)在空腹清醒状态下进行研究。有糖尿病和有左前降支血管床心肌梗死史的患者被排除在研究之外。患者在动脉和冠状静脉窦置管期间注射185-MBq(5-MCI)FDG。注射FDG后30min，取成对的基底动脉血和冠状静脉窦血，测定FDG和葡萄糖摄取率。然后，用正糖钳夹技术连续(100muxm(-2)xmin(-1))持续(50muxm(-2)xmin(-1))输注胰岛素60min，重复采集血样。定期采集血样，测定动脉血中游离脂肪酸和胰岛素水平。
结果
正常血糖胰岛素输注可降低动脉血中游离脂肪酸的浓度，使心肌中游离脂肪酸的提取减少85%，并刺激葡萄糖和FDG的摄取。心肌葡萄糖和FDG提取分数(%)从基线时的1+/-1和2+/-2分别增加到胰岛素输注期间的8+/-2和10+/-3。空腹状态的集总常数值为1.44+/-0.14(r=0.87)，胰岛素输注时为0.99+/-0.07(r=0.74)，合并后为1.00+/-0.05(r=0.92)。
结论
在这项研究中获得的数据表明，FDG摄取定量跟踪缺血性心脏病患者生理性高胰岛素血症期间的葡萄糖摄取。
UNLABELLED
This study was performed to evaluate the effect of insulin on myocardial kinetics of 18F-fluorodeoxyglucose (FDG) and glucose in patients with ischemic heart disease.
METHODS
Twelve male patients (age range 54-79 yr; mean age 69 +/- 8 yr) were studied during the fasting awake state. Patients with diabetes and previous myocardial infarction of the left anterior descending vascular bed were excluded from the study. Patients were injected with a 185-MBq (5-mCi) bolus of FDG during arterial and coronary sinus catheterization. Thirty minutes after FDG injection, paired basal arterial and coronary sinus blood samples were taken for the measurement of FDG and glucose uptake. Thereafter, a primed (100 mU x m(-2) x min(-1) for 10 min) continuous (50 mU x m(-2) x min(-1) infusion of insulin was administered for 60 min using the euglycemic clamp technique, and blood samples were repeated. Blood samples also were taken periodically for the measurement of arterial free fatty acids and insulin.
RESULTS
Euglycemic insulin infusion lowered arterial concentrations of free fatty acids, reducing myocardial extraction of free fatty acids by 85% and stimulated uptake of glucose and FDG. Myocardial glucose and FDG extraction fractions (%) increased from 1 +/- 1 and 2 +/- 2 at baseline to 8 +/- 2 and 10 +/- 3 during insulin infusion, respectively. The lumped constant value was estimated to be 1.44 +/- 0.14 (r = 0.87) for the fasted state, 0.99 +/- 0.07 (r = 0.74) during insulin infusion and 1.00 +/- 0.05 (r = 0.92) when both groups of data were pooled together.
CONCLUSION
The data obtained in this study show that FDG uptake quantitatively traces glucose uptake during physiological hyperinsulinemia in patients with ischemic heart disease.
大鼠心脏中己糖激酶的区室。
DOI：
10.1172/jci116076
发表时间：
1992
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
Russell3rd,RR;Mrus,JM;Mommessin,JI;Taegtmeyer,H
通讯作者：
Taegtmeyer,H
DOI：
10.1016/0883-2889(89)90213-x
发表时间：
1989
期刊：
International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes
影响因子：
--
作者：
H. Padgett;D. Schmidt;A. Luxen;G. Bida;N. Satyamurthy;J. Barrio
通讯作者：
H. Padgett;D. Schmidt;A. Luxen;G. Bida;N. Satyamurthy;J. Barrio
[5-3H]葡萄糖和[U-14C]脱氧葡萄糖作为再灌注心肌糖酵解标记物之间的相关性。
影响因子：
20.1
作者：
Liedtke,AJ;Renstrom,B;Nellis,SH
通讯作者：
Nellis,SH