Cutting Edge: Immediate RANTES Secretion by Resting Memory CD8 T Cells Following Antigenic Stimulation 1
Cutting Edge: Immediate RANTES Secretion by Resting Memory CD8 T Cells Following Antigenic Stimulation 1
复制标题
尖端技术:抗原刺激后静息记忆 CD8 T 细胞立即分泌 RANTES 1
DOI:
10.4049/jimmunol.170.4.1615
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发表时间:
2003
期刊:
影响因子:
--
通讯作者:
J. Marvel
中科院分区:
文献类型:
--
作者:
T. Walzer;A. Marçais;F. Saltel;C. Bella;P. Jurdic;J. Marvel
The efficiency of CD8 memory response relies partially on the modification of cellular functional capacities. To identify effector functions that can be modified following priming, we have compared the chemokines produced by naive and memory CD8 T cells. Our results show that in contrast to naive cells, resting memory CD8 T cells contain high levels of RANTES mRNA. As a result, they have the capacity to rapidly secrete RANTES upon ex vivo antigenic stimulation. In contrast to that of IFN-γ, RANTES secretion is mainly due to the translation of the pre-existing mRNA.
影响因子:
32.4
作者:
Agarwal, S;Rao, A
通讯作者:
Rao, A
DOI:
--
发表时间:
1998
期刊:
Journal of immunology (Baltimore, Md. : 1950)
影响因子:
--
作者:
Kedl,RM;Mescher,MF
通讯作者:
Mescher,MF