Catalytic Antioxidants as Novel Pharmacologic Approaches to Treatment of Ischemic Brain Injury.
Catalytic Antioxidants as Novel Pharmacologic Approaches to Treatment of Ischemic Brain Injury.
复制标题
催化抗氧化剂作为治疗缺血性脑损伤的新药理学方法。
作者：
H. Sheng;Ines Batinc;D. Warner
急性脑缺血后活性氧（ROS）和活性氮（RNS）增加。这些物种与继发性损伤有关，继发性损伤会放大最终神经元损伤的程度。生化分析和转基因小鼠的研究表明，ROS/RNS 的产生在初次损伤后持续数小时。这为临床相关的药物干预提供了潜在的治疗窗口。已经合成了几类超氧化物歧化酶/过氧化氢酶的药理学模拟物。在急性脑损伤的实验室模型中对这些催化抗氧化剂的评估表明，在明显无神经毒性的剂量下，它们具有强大的神经保护作用和延长的治疗窗口。 (c) 2002 年《Prous Science》。版权所有。
Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are increased following acute brain ischemia. These species have been associated with secondary injury that amplifies the magnitude of final neuronal damage. Work with both biochemical analyses and transgenic mice has shown that ROS/RNS production persists for many hours after the initial insult. This offers a potential therapeutic window for pharmacologic intervention of clinical relevance. Several classes of pharmacologic mimetics of superoxide dismutase/catalase have been synthesized. Evaluation of these catalytic antioxidants in laboratory models of acute brain injury has shown both robust neuroprotection and a prolonged therapeutic window at doses apparently devoid of neurotoxicity. (c) 2002 Prous Science. All rights reserved.