Sequence elements that affect mRNA translational activity in developing Dictyostelium cells.
Sequence elements that affect mRNA translational activity in developing Dictyostelium cells.
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影响发育中盘基网柄菌细胞中 mRNA 翻译活性的序列元件。
DOI：
10.1002/dvg.1020120117
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Jacobson,A
中科院分区：
文献类型：
--
作者：
Steel,LF;Jacobson,A
Post‐transcriptional controls, including changes in both mRNA translational activity and stability, play an important role in the regulation of ribosomal protein gene expression in developingDictyostelium discoideumcells. Previously we have shown that the mechanisms which regulate the translational activity of the r‐protein mRNAs operate at the level of translational initiation and do not involve changes in polyadenylation or capping. By analysing the translational behavior of chimeric and mutant mRNAs in transformed cells, we have now been able to localize the determinants of translational activity of one of the r‐protein mRNAs to the 5′‐untranslated region. Although this and other r‐protein mRNAs differ strikingly from theDictyosteliumconsensus in the region of the initiator AUG codon, we find that improving the match to that consensus does not increase the translational activity of the message in developing cells. Current experiments are designed to determine whether translational regulation is mediated by strong interactions with specific inhibitors or by weak interactions with translational initiation factors.
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DOI：
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期刊：
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