Metabolic associated fatty liver disease increases coronavirus disease 2019 disease severity in nondiabetic patients
Metabolic associated fatty liver disease increases coronavirus disease 2019 disease severity in nondiabetic patients
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DOI：
10.1111/jgh.15112
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发表时间：
2020-06-05
影响因子：
4.1
通讯作者：
Zheng, Ming-Hua
中科院分区：
文献类型：
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作者：
Gao, Feng;Zheng, Kenneth, I;Zheng, Ming-Hua
背景及目的2019冠状病毒病（COVID-19）日益引起全球关注。虽然已知糖尿病会加重COVID-19的严重程度，但尚不清楚患有代谢功能障碍的非糖尿病患者是否也更容易患上更严重的疾病。研究非糖尿病患者中代谢相关性脂肪肝（MAFLD）与COVID-19严重程度的相关性。方法研究队列包括65例MAFLD患者（即病例）和65例非MAFLD患者（即对照）。每个病例按性别（1：1）和年龄（+/- 5岁）与一个对照组随机匹配。结果在非糖尿病COVID-19患者中，MAFLD的存在与严重COVID-19的风险增加4倍相关;风险随着代谢危险因素数量的增加而增加。在调整年龄、性别和共存疾病条件后，与COVID-19严重程度的相关性仍然存在。结论护理非糖尿病COVID-19患者的医疗保健专业人员应认识到MAFLD患者发生严重COVID-19的可能性增加。
Background and Aim Coronavirus disease 2019 (COVID-19) has attracted increasing worldwide attention. While diabetes is known to aggravate COVID-19 severity, it is not known whether nondiabetic patients with metabolic dysfunction are also more prone to more severe disease. The association of metabolic associated fatty liver disease (MAFLD) with COVID-19 severity in nondiabetic patients was investigated here.Methods The study cohort comprised 65 patients with (i.e. cases) and 65 patients without MAFLD (i.e. controls). Each case was randomly matched with one control by sex (1:1) and age (+/- 5 years). The association between the presence of MAFLD (as exposure) and COVID-19 severity (as the outcome) was assessed by binary logistic regression analysis.Results In nondiabetic patients with COVID-19, the presence of MAFLD was associated with a four-fold increased risk of severe COVID-19; the risk increased with increasing numbers of metabolic risk factors. The association with COVID-19 severity persisted after adjusting for age, sex, and coexisting morbid conditions.Conclusion Health-care professionals caring for nondiabetic patients with COVID-19 should be cognizant of the increased likelihood of severe COVID-19 in patients with MAFLD.