NOTCH, APOPTOSIS AND CANCER
NOTCH, APOPTOSIS AND CANCER
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DOI：
10.1007/978-1-4614-0899-4_15
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发表时间：
2012-01-01
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影响因子：
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通讯作者：
Dang, Thao P.
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文献类型：
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作者：
Dang, Thao P.
正常的胚胎发育和正常的组织动态平衡需要一系列的分子过程，调节细胞的生长、分化和凋亡。这些过程中的任何一个过程的扰动都会导致癌症的发展。特别是，在几乎所有类型的人类癌症中都可以看到细胞凋亡的缺陷。在胚胎发育和器官动态平衡中，Notch通路在决定细胞命运中起着重要作用。不足为奇的是，当Notch的调节失调时，它也在癌症中发挥作用。在这一章中，我们将探索Notch信号如何与调节癌症细胞凋亡的关键途径相互作用。特别是，我们将集中在Notch和负责激活caspase途径的蛋白质之间的关系。Notch通过广泛的网络调节细胞凋亡，涉及细胞周期、生长和生存途径。因此，我们还将研究Notch与其他信号通路(如P53、NF-kappa B和PI3K-Akt通路)之间的串扰是如何调节细胞凋亡的。
Proper embryonic development and normal tissue homeostasis require a series of molecular processes, regulating cell growth, differentiation and apoptosis. Perturbation in any of these processes invariably contributes to the development of cancer. In particular, defects in apoptosis are seen in virtually all types of human cancers. The Notch pathway plays an important role in cell fate determination in both embryonic development and organ homeostasis. Not surprisingly, Notch also plays a role in cancer when it is dysregulated. In this chapter, we will explore how Notch signaling interacts with key pathways that regulate apoptosis in cancer. Particularly, we will focus on the relationship between Notch and proteins responsible for activation of the caspase pathway. Notch regulates apoptosis through extensive networks, involving cell cycle, growth and survival pathways. Thus, we will also examine how apoptosis is modulated by the crosstalk between Notch and other signaling pathways such as p53, NF-kappa B and PI3K-Akt pathways.