Sudden sensorineural hearing loss: A vascular cause? Analysis of prothrombotic risk factors in head and neck
Sudden sensorineural hearing loss: A vascular cause? Analysis of prothrombotic risk factors in head and neck
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DOI：
10.3109/14992027.2012.705904
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发表时间：
2012-11-01
影响因子：
2.7
通讯作者：
Marco, de Vincentiis
中科院分区：
文献类型：
--
作者：
Massimo, Fusconi;Antonio, Chistolini;Marco, de Vincentiis
目的：本研究的目的是确定突发感音神经性耳聋、视网膜中央静脉阻塞和小血管疾病相关卒中中血栓形成危险因素的患病率，目的是调查和加强突发感音神经性耳聋发病机制中的血管假说。设计：病例对照研究。将这三组的遗传和获得性危险因素与健康对照组进行比较。研究样本：在三年的时间里，分别有49、60和101名患者患有突发性感音神经性听力损失、视网膜中央静脉阻塞或与小血管疾病相关的中风，并与210名健康对照者进行了比较。结果：高同型半胱氨酸血症（同型半胱氨酸>= 15 μ mol/L）的发生率在各疾病组均高于对照组。在所有三种疾病中，MTHFR C677 T突变和高同型半胱氨酸血症之间存在统计学显著的相关性，尽管相关性较弱。结论：高同型半胱氨酸血症是突发性耳聋的危险因素。基于这些结果，我们建议分析同型半胱氨酸在突发感音神经性耳聋患者，如果其值是高的，以评估MTHFR C677 T突变的存在。
Objective: This aim of this study was to determine the prevalence of thrombophilic risk factors in sudden sensorineural hearing loss, central retinal vein occlusion, and stroke associated with small vessel disease, with the purpose of investigating and reinforcing the vascular hypothesis in the pathogenesis of sudden sensorineural hearing loss. Design: Case-control study. Genetic and acquired risk factors of these three groups were compared with healthy controls. Study sample: Forty-nine, 60, and 101 patients affected respectively by sudden sensorineural hearing loss, central retinal vein occlusion, or stroke associated with small vessel disease, enrolled during a three-year period were compared with 210 healthy controls. Results: The frequency of hyperhomocysteinemia (homocysteine >= 15 mu mol/L) was higher in each disease group than in controls. A statically significant, albeit weak, correlation between the MTHFR C677T mutation and hyperhomocysteinemia was found in all three diseases. Conclusions: Hyperhomocysteinemia proved to be a risk factor for sudden sensorineural hearing loss. Based on these results, we propose to analyse homocysteine in sudden sensorineural hearing loss patients and, if its values are high, to evaluate the presence of MTHFR C677T mutation.