PATHOGENESIS OF LIVER CIRRHOSIS IN SCHISTOSOMIASIS
PATHOGENESIS OF LIVER CIRRHOSIS IN SCHISTOSOMIASIS
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DOI：
10.1001/jama.1951.03670210016005
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发表时间：
1951-01-01
影响因子：
120.7
通讯作者：
SYMMERS, D
中科院分区：
文献类型：
--
作者：
SYMMERS, D
5例中有2例表现为肝小叶周围间隙的肝硬变，伴有血吸虫局灶性肉芽肿，但与血管壁或实质细胞间的血吸虫局灶性肉芽肿无关。在第三个病例中，肝脏是慢性被动充血的部位，并伴有小叶间纤维化的斑片状区域。血吸虫卵周围散在分布着许多小肉芽肿。在其余2例中，肝脏的改变几乎仅限于血吸虫卵子周围偶见的实质肉芽肿。仅靠卵子不被认为能够引起小叶周围肝硬变；后者被认为是由于患者生活在恶劣的饮食条件下。
In 2 of the 5 cases synopsized, cirrhotic changes in perilobular spaces of the liver were present, attended by but independent of focal schistosomal granulomas in the walls of blood vessels or among the parenchymal cells. In a third case the liver was the seat of chronic passive congestion, together with patchlike areas of interlobular fibrosis. Scattered throughout were numerous small granulomas arranged around the ova of schistosomes. In the remaining 2 cases the changes in the liver were limited practically exclusively to occasional parenchymal granulomas around schistosome ova. Ova alone are not considered capable of causing perilobular cirrhosis of the liver; the latter is believed attributable to poor dietary conditions under which the patients live.